ND: |
ME11214126 |
PMID: |
11214126 |
LR: |
20061115 |
CED: |
20010213 |
DCO: |
20010222 |
Autoren: |
Reginster JY; Deroisy R; Rovati LC; Lee RL; Lejeune E; Bruyere O; Giacovelli G; Henrotin Y; Dacre JE; Gossett C |
Titel: |
Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. |
Quelle: |
Lancet; VOL: 357 (9252); p. 251-6 /20010127/ |
PM: |
Print |
SU: |
AIM IM |
Sprache: |
English |
CY: |
England |
JID: |
2985213R |
ISSN: |
0140-6736 |
CO: |
LANCAO |
Institution: |
Bone and Cartilage Metabolism Research Unit (WHO Collaborating Center for Public Aspects of Osteoarticular Disorders), University of Liege, Belgium. jyreginster@ulg.ac.be |
DT: |
Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Schlagwörter |
CT: |
ADMINISTRATION, ORAL; AGED; DIETARY SUPPLEMENTS/*; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; GLUCOSAMINE/*therapeutic use; HUMANS; KNEE JOINT/radiography; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE/*drug therapy; OSTEOARTHRITIS, KNEE/radiography; PLACEBOS; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME |
CTG: |
APPLIKATION, ORALE; ALTE MENSCHEN; NAHRUNGSERGÄNZUNGSMITTEL/*; KRANKHEITSPROGRESSION; DOPPELBLINDMETHODE; WEIBLICH; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; KNIEGELENK/Röntgenuntersuchung; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; OSTEOARTHROSE, KNIE/Röntgenuntersuchung; PLAZEBOS; STATISTIK, NICHTPARAMETRISCHE; BEHANDLUNGSERGEBNIS |
TE: |
Placebos; Glucosamine/3416-24-8 |
CR: |
3416-24-8 |
NOTE: |
Comment in: Clin J Sport Med. 2002 Mar;12(2):136; Ref.PMID: 11980439; Comment in: Lancet. 2001 Jan 27;357(9252):247-8; Ref.PMID: 11214122; Comment in: Lancet. 2001 May 19;357(9268):1617-8; Ref.PMID: 11386309; Comment in: Lancet. 2001 May 19;357(9268):1617; author reply 1618; Ref.PMID: 11386310; Comment in: Lancet. 2001 May 19;357(9268):1617; author reply 1618; Ref.PMID: 11386311; Comment in: Lancet. 2001 May 19;357(9268):1617; author reply 1618; Ref.PMID: 11386312 |
AB: |
BACKGROUND: Treatment of osteoarthritis is usually limited to short-term symptom control. We assessed the effects of the specific drug glucosamine sulphate on the long-term progression of osteoarthritis joint structure changes and symptoms. METHODS: We did a randomised, double-blind placebo controlled trial, in which 212 patients with knee osteoarthritis were randomly assigned 1500 mg sulphate oral glucosamine or placebo once daily for 3 years. Weightbearing, anteroposterior radiographs of each knee in full extension were taken at enrolment and after 1 and 3 years. Mean joint-space width of the medial compartment of the tibiofemoral joint was assessed by digital image analysis, whereas minimum joint-space width--ie, at the narrowest point--was measured by visual inspection with a magnifying lens. Symptoms were scored by the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index. FINDINGS: The 106 patients on placebo had a progressive joint-space narrowing, with a mean joint-space loss after 3 years of -0.31 mm (95% CI -0.48 to -0.13). There was no significant joint-space loss in the 106 patients on glucosamine sulphate: -0.06 mm (-0.22 to 0.09). Similar results were reported with minimum joint-space narrowing. As assessed by WOMAC scores, symptoms worsened slightly in patients on placebo compared with the improvement observed after treatment with glucosamine sulphate. There were no differences in safety or reasons for early withdrawal between the treatment and placebo groups. INTERPRETATION: The long-term combined structure-modifying and symptom-modifying effects of gluosamine sulphate suggest that it could be a disease modifying agent in osteoarthritis. |