ND: |
ME10693368 |
PMID: |
10693368 |
LR: |
20041117 |
CED: |
20000316 |
DCO: |
20000316 |
Autoren: |
Rindone JP; Hiller D; Collacott E; Nordhaugen N; Arriola G |
Titel: |
Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. |
Quelle: |
The Western journal of medicine; VOL: 172 (2); p. 91-4 /200002/ |
PM: |
Print |
SU: |
AIM IM |
Sprache: |
English |
CY: |
UNITED STATES |
JID: |
0410504 |
ISSN: |
0093-0415 |
CO: |
WJMDA2 |
Institution: |
Veterans Affairs Medical Center, Prescott, AZ 86313, USA. joseph.rindone@med.va.gov |
DT: |
Clinical Trial; Journal Article; Randomized Controlled Trial |
Schlagwörter |
CT: |
AGED; DOUBLE-BLIND METHOD; FEMALE; GLUCOSAMINE/*therapeutic use; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE/*drug therapy; TREATMENT OUTCOME |
CTG: |
ALTE MENSCHEN; DOPPELBLINDMETHODE; WEIBLICH; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; BEHANDLUNGSERGEBNIS |
TE: |
Glucosamine/3416-24-8 |
CR: |
3416-24-8 |
NOTE: |
Comment in: West J Med. 2000 Feb;172(2):95; Ref.PMID: 10693369 |
AB: |
OBJECTIVE: To determine the effectiveness of glucosamine in reducing pain from osteoarthritis of the knee. DESIGN: Randomized, double-blind parallel trial of glucosamine 500 mg three times daily or a placebo for 2 months. SETTING: Veterans Affairs Medical Center, Prescott, AZ. PARTICIPANTS: Ninety-eight patients aged 34 to 81 being treated for osteoarthritis of the knee. MAIN OUTCOME MEASURES: Pain intensity both at rest and while walking as assessed by a visual analog scale at baseline and after 30 and 60 days of treatment. RESULTS: Forty-nine patients were randomly allocated to each group. There was no statistical difference between the two groups in scores on the visual analog scale at 30 days for resting (mean [SD] score placebo group 3.5 [2.7] vs 3.3 [2.4] glucosamine group, P = 0.66) or walking (5.1 [2.6] vs 5.3 [2.4], P = 0.69); there was also no difference at 60 days for resting (3.4 [2.5] vs 3.2 [2.5], P = 0.81) or walking (4.9 [2.2] vs 4.9 [2.8], P = 0.90). There was also no statistical difference between groups in the mean change from baseline in scores on the visual analog scale (mean [SD] change for walking at 60 days placebo group -1.5 [2.5] vs glucosamine group -1.4 [3.0], P = 0.77). Two participants taking glucosamine and 4 taking placebo withdrew from the study due to adverse side effects (P = 0.67). CONCLUSION: Glucosamine was no better than placebo in reducing pain from osteoarthritis of the knee in this group of patients. |