ND: |
ME12186848 |
PMID: |
12186848 |
LR: |
20051116 |
CED: |
20020820 |
DCO: |
20021008 |
Autoren: |
Freeze HH |
Titel: |
Sweet solution: sugars to the rescue. |
Quelle: |
The Journal of cell biology; VOL: 158 (4); p. 615-6 /20020819/ |
PM: |
Print-Electronic |
EPD: |
20020819 |
SU: |
IM |
Sprache: |
English |
CY: |
United States |
JID: |
0375356 |
ISSN: |
0021-9525 |
CO: |
JCLBA3 |
Institution: |
The Burnham Institute, La Jolla Cancer Research Center, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA. hudson@burnham.org |
DT: |
Comment; Journal Article; Review |
RN: |
17 |
Schlagwörter |
CT: |
ANIMALS; CARRIER PROTEINS/genetics; COLITIS/drug therapy; COLITIS/etiology; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; FUCOSE/metabolism; FUCOSE/*therapeutic use; GLUCOSAMINE/*analogs & derivatives; GLUCOSAMINE/therapeutic use; GUANOSINE DIPHOSPHATE FUCOSE/*metabolism; HUMANS; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME/*drug therapy; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME/genetics; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME/metabolism; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME/physiopathology; MICE; MICE, KNOCKOUT; MONOSACCHARIDE TRANSPORT PROTEINS/*; MUTATION; OSTEOARTHRITIS/drug therapy; OSTEOARTHRITIS/etiology |
CTG: |
TIER; CARRIERPROTEINE/Genetik; KOLITIS/Arzneimitteltherapie; KOLITIS/Ätiologie; NAHRUNGSERGÄNZUNGSMITTEL; KRANKHEITSMODELLE, TIER; FUCOSE/Stoffwechsel; FUCOSE/*therapeutische Anwendung; GLUCOSAMIN/*Analoge & Derivate; GLUCOSAMIN/therapeutische Anwendung; GUANOSINDIPHOSPHAT-FUCOSE/*Stoffwechsel; MENSCH; LEUKOZYTEN-ADHÄSIONSMANGEL-SYNDROM/*Arzneimitteltherapie; LEUKOZYTEN-ADHÄSIONSMANGEL-SYNDROM/Genetik; LEUKOZYTEN-ADHÄSIONSMANGEL-SYNDROM/Stoffwechsel; LEUKOZYTEN-ADHÄSIONSMANGEL-SYNDROM/Pathophysiologie; MÄUSE; MÄUSE, KNOCKOUT-; MONOSACCHARID-TRANSPORTPROTEINE/*; MUTATION; OSTEOARTHROSE/Arzneimitteltherapie; OSTEOARTHROSE/Ätiologie |
TE: |
Carrier Proteins; Monosaccharide Transport Proteins; SLC35C1 protein, human; Guanosine Diphosphate Fucose/15839-70-0; Glucosamine/3416-24-8; Fucose/3713-31-3; N-acetylglucopyranosylamine/6983-36-4 |
CR: |
15839-70-0; 3416-24-8; 3713-31-3; 6983-36-4 |
NOTE: |
Comment on: J Cell Biol. 2002 Aug 19;158(4):801-15; Ref.PMID: 12186857 |
AB: |
Sugar pills are usually placebos, but Smith et al. (2002, this issue) use one to rescue designer mice unable to make GDP-Fucose. Dietary fucose enters a salvage pathway and spares the mice. Sound simple? Not so. Unknown genetic factors determine life or death. |