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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: ME09080302
PMID: 9080302
LR: 20061115
CED: 19970626
DCO: 19970626
Autoren: Bond A; Alavi A; Axford JS; Bourke BE; Bruckner FE; Kerr MA; Maxwell JD; Tweed KJ; Weldon MJ; Youinou P; Hay FC
Titel: A detailed lectin analysis of IgG glycosylation, demonstrating disease specific changes in terminal galactose and N-acetylglucosamine.
Quelle: Journal of autoimmunity; VOL: 10 (1); p. 77-85 /199702/
PM: Print
SU: IM
Sprache: English
CY: ENGLAND
JID: 8812164
ISSN: 0896-8411
CO: JOAUEP
Institution: Division of Immunology, St George's Hospital Medical School, London. a.bond@sghms.ac.uk
DT: Journal Article; Research Support, Non-U.S. Gov't
Schlagwörter
CT: ACETYLGLUCOSAMINE/*metabolism; ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID/immunology; ARTHRITIS, RHEUMATOID/metabolism; GALACTOSE/*metabolism; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN G/*metabolism; LECTINS/metabolism; MIDDLE AGED; OLIGOSACCHARIDES/metabolism; SJOGREN'S SYNDROME/immunology; SJOGREN'S SYNDROME/metabolism
CTG: ACETYLGLUCOSAMIN/*Stoffwechsel; ERWACHSENER; ALTE MENSCHEN; ALTE MENSCHEN, 80 JAHRE UND ÄLTER; ARTHRITIS, RHEUMATOIDE/Immunologie; ARTHRITIS, RHEUMATOIDE/Stoffwechsel; GALACTOSE/*Stoffwechsel; GLYCOSYLIERUNG; MENSCH; IMMUNGLOBULIN G/*Stoffwechsel; LECTINE/Stoffwechsel; MENSCHEN IM MITTLEREN LEBENSALTER; OLIGOSACCHARIDE/Stoffwechsel; SJÖGREN-SYNDROM/Immunologie; SJÖGREN-SYNDROM/Stoffwechsel
TE: Immunoglobulin G; Lectins; Oligosaccharides; Galactose/26566-61-0; Acetylglucosamine/7512-17-6
CR: 26566-61-0; 7512-17-6
AB: Serum IgG from rheumatoid arthritis patients contains a decreased number of oligosaccharide structures ending in galactose and thus there is an increase in N-acetylglucosamine as the terminal sugar, compared with healthy individuals. The relationship between these two sugars varies depending on the disease examined: IgG from patients with rheumatoid arthritis, juvenile onset chronic arthritis and Crohn's disease are at one extreme, and exhibit a reciprocal galactose:N-acetylglucosamine relationship, while Sjögren's syndrome and osteoarthritis IgG are at the other extreme, exhibiting a parallel increase in the expression of both galactose and N-acetylglucosamine. These results may occur as a consequence of more than one glycosylation site which is differentially glycosylated, but more likely by changes in the level of bisecting N-acetylglucosamine.
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