Dokumente
Suchschritt : FT=glucosamine AND FT=osteoarthritis
» Fenster schließen »

2/15 von 414 DIMDI: MEDLINE (ME60) © NLM

ND: | ME16818461
PMID: | 16818461
CED: | 20070123
Autoren: | Biggee BA; Blinn CM; Nuite M; Silbert JE; McAlindon TE
Titel: | Effects of oral glucosamine sulphate on serum glucose and insulin during an oral glucose tolerance test of subjects with osteoarthritis.
Quelle: | Annals of the rheumatic diseases; VOL: 66 (2); p. 260-2 /200702/
PM: | Print-Electronic
EPD: | 20060703
SU: | IM
Sprache: | English
CY: | England
JID: | 0372355
ISSN: | 0003-4967
CO: | ARDIAO
Institution: | Division of Rheumatology, Tufts New England Medical Center, Boston, Massachusetts, USA.
DT: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
NG: | M01-RR00054 RR NCRR; T-32 PHS
AB: | BACKGROUND: and objective: Glucosamine is suggested to affect glucose transport and insulin resistance. The effects of oral glucosamine on serum glucose and insulin levels at the initiation and throughout the duration of a 3-h oral glucose tolerance test were examined. METHODS: Sera from 16 patients with osteoarthritis, but with no other diagnosed medical condition who had fasted overnight, were obtained every 15-30 min during the 3 h of continued fasting and during the 3 h after ingestion of 75 g of glucose with or without ingestion of 1500 mg of glucosamine sulphate. Glucose was analysed by high-performance liquid chromatography using a Metrohm-Peak 817 Bioscan, and the area under the curve (AUC) for glucose was calculated. Insulin was measured by radioimmunoassay every 30 min for 2 h. RESULTS: Three participants who were found to have previously undiagnosed abnormalities of glucose tolerance demonstrated significant (p = 0.04) incremental elevations in glucose levels after ingestion of glucosamine sulphate. The other 13 participants also had mean incremental elevations that were not significant (p = 0.20). Glucosamine sulphate ingestion had no effect on insulin levels. CONCLUSION: The results suggest that glucosamine ingestion may affect glucose levels and consequent glucose uptake in patients who have untreated diabetes or glucose intolerance.

» Volltext »
» Fenster schließen »