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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME07326065
PMID: | 7326065
LR: | 20061115
CED: | 19820326
DCO: | 19820326
Autoren: | Schwartz ER; Leveille CR; Stevens JW; Oh WH
Titel: | Proteoglycan structure and metabolism in normal and osteoarthritic cartilage of guinea pigs.
Quelle: | Arthritis and rheumatism; VOL: 24 (12); p. 1528-39 /198112/
PM: | Print
SU: | AIM IM
Sprache: | English
CY: | UNITED STATES
JID: | 0370605
ISSN: | 0004-3591
CO: | ARHEAW
DT: | Journal Article; Research Support, U.S. Gov't, P.H.S.
NG: | AM 22149 AM NIADDK
Schlagwörter
CT: | ANIMALS; ASCORBIC ACID/pharmacology; CARTILAGE, ARTICULAR/analysis; CARTILAGE, ARTICULAR/*metabolism; CARTILAGE, ARTICULAR/pathology; CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS; GUINEA PIGS; OSTEOARTHRITIS/*metabolism; PROTEOCHONDROITIN SULFATES/biosynthesis; PROTEOGLYCANS/analysis; PROTEOGLYCANS/*metabolism; REFERENCE VALUES; TISSUE DISTRIBUTION
CTG: | TIER; ASCORBINSÄURE/Pharmakologie; KNORPEL, GELENK-/Analyse; KNORPEL, GELENK-/*Stoffwechsel; KNORPEL, GELENK-/Pathologie; CHEMIE; CHROMATOGRAPHIE, HOCHDRUCK-FLÜSSIGKEITS-; ELEKTROPHORESE; MEERSCHWEINCHEN; OSTEOARTHROSE/*Stoffwechsel; PROTEOCHONDROITIN-SULFATE/Biosynthese; PROTEOGLYCANE/Analyse; PROTEOGLYCANE/*Stoffwechsel; REFERENZWERTE; GEWEBEVERTEILUNG
TE: | Proteochondroitin Sulfates; Proteoglycans; Ascorbic Acid/50-81-7
CR: | 50-81-7
AB: | Sulfated proteoglycan structure and metabolism in osteoarthritic articular cartilage from the hind-limb joints of guinea pigs in which the disease had been surgically induced were evaluated and compared with those from nonoperated or sham-operated controls. In these studies, conducted on animals receiving high and low dietary levels of ascorbic acid, the effect of vitamin C on these variables was also examined. Sulfated proteoglycan biosynthesis per unit of DNA as reflected by in vivo uptake of 35S-sulfate was stimulated both by arthritic development and high dietary vitamin C. Under these conditions, the specific activities, 35S-cpm/micrograms uronic acid, of the proteoglycans were elevated. Neither arthritic development nor variation in dietary levels of vitamin C altered the structure of the proteoglycans. Two species of proteoglycans that exhibited the same electrophoretic mobilities in agarose/acrylamide gels, the same elution profiles on high performance liquid chromatography,, and the same galactosamine/glucosamine ratios were found in all normal and osteoarthritic cartilage specimens tested. The specific activities of these two specimens tested. The specific activities of these two species were dissimilar. In all samples, the larger of the two species had a higher specific activity.

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