Dokumente
Suchschritt : FT=glucosamine AND FT=osteoarthritis
» Fenster schließen »

2/127 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME15608304
PMID: | 15608304
LR: | 20061115
CED: | 20041220
DCO: | 20050217
Autoren: | Shikhman AR; Amiel D; D'Lima D; Hwang SB; Hu C; Xu A; Hashimoto S; Kobayashi K; Sasho T; Lotz MK
Titel: | Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis.
Quelle: | Annals of the rheumatic diseases; VOL: 64 (1); p. 89-94 /200501/
PM: | Print
SU: | IM
Sprache: | English
CY: | England
JID: | 0372355
ISSN: | 0003-4967
CO: | ARDIAO
Institution: | Division of Arthritis Research, The Scripps Research Institute, La Jolla, CA, USA. shikhman@scripps.edu
DT: | Journal Article; Research Support, U.S. Gov't, P.H.S.
NG: | AG07996 AG NIA; AR46990 AR NIAMS; AT00052 AT NCCAM
Schlagwörter
CT: | ACETYLGLUCOSAMINE/*therapeutic use; ANIMALS; ANTIRHEUMATIC AGENTS/*therapeutic use; ARTHRITIS, EXPERIMENTAL/pathology; ARTHRITIS, EXPERIMENTAL/*prevention & control; HYALURONIC ACID/therapeutic use; INJECTIONS, INTRA-ARTICULAR; INJECTIONS, INTRAMUSCULAR; OSTEOARTHRITIS/pathology; OSTEOARTHRITIS/*prevention & control; RABBITS; SYNOVIAL MEMBRANE/pathology; SYNOVITIS/prevention & control
CTG: | ACETYLGLUCOSAMIN/*therapeutische Anwendung; TIER; ANTIRHEUMATIKA/*therapeutische Anwendung; ARTHRITIS, EXPERIMENTELLE/Pathologie; ARTHRITIS, EXPERIMENTELLE/*Verhütung & Bekämpfung; HYALURONSÄURE/therapeutische Anwendung; INJEKTIONEN, INTRAARTIKULÄRE; INJEKTIONEN, INTRAMUSKULÄRE; OSTEOARTHROSE/Pathologie; OSTEOARTHROSE/*Verhütung & Bekämpfung; KANINCHEN; SYNOVIALMEMBRAN/Pathologie; SYNOVITIS/Verhütung & Bekämpfung
TE: | Antirheumatic Agents; Acetylglucosamine/7512-17-6; Hyaluronic Acid/9004-61-9
CR: | 7512-17-6; 9004-61-9
AB: | OBJECTIVE: To examine the therapeutic efficacy of N-acetylglucosamine (GlcNAc) in rabbits with experimental osteoarthritis (OA). METHODS: Experimental OA was induced in rabbits by anterior cruciate ligament transection (ACLT). In the first study, rabbits (six in each group) received intramuscular injections of GlcNAc or normal saline three times a week starting 1 week postoperatively. In the second study, rabbits (eight in each group) were injected intra-articularly with GlcNAc (either once or twice a week) or normal saline. In the third study, rabbits (seven in each group) were injected intra-articularly twice a week with either GlcNAc, hyaluronan, or normal saline. Animals were killed 8 weeks after ACLT for macroscopic and histological assessment of the knee joints. RESULTS: Intramuscular administration of GlcNAc in rabbits with experimental knee OA did not show chondroprotective effects but showed mild anti-inflammatory activity. In contrast, intra-articular administration of GlcNAc twice a week reduced cartilage degradation. Additionally, intra-articular GlcNAc also suppressed synovitis. Once a week intra-articular injections of GlcNAc did not demonstrate therapeutic efficacy. The chondroprotective efficacy of GlcNAc was better than that of viscosupplementation treatment with hyaluronan. CONCLUSION: Intra-articular GlcNAc has chondroprotective and anti-inflammatory activity in experimental OA.

» Volltext »
» Fenster schließen »