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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME07371310
PMID: | 7371310
LR: | 20061115
CED: | 19800722
DCO: | 19800722
Autoren: | Floman Y; Eyre DR; Glimcher MJ
Titel: | Induction of osteoarthrosis in the rabbit knee joint: biochemical studies on the articular cartilage.
Quelle: | Clinical orthopaedics and related research (147); p. 278-86 /1980 Mar-Apr/
PM: | Print
SU: | AIM IM
Sprache: | English
CY: | UNITED STATES
JID: | 0075674
ISSN: | 0009-921X
CO: | CORTBR
DT: | Journal Article; Research Support, U.S. Gov't, P.H.S.
Schlagwörter
CT: | ANIMALS; CARTILAGE, ARTICULAR/*metabolism; COLLAGEN/analysis; COLLAGEN/*biosynthesis; DISEASE MODELS, ANIMAL; FEMALE; GALACTOSAMINE/metabolism; GLUCOSAMINE/metabolism; HYDROXYPROLINE/*metabolism; KNEE JOINT/metabolism; MOLECULAR CONFORMATION; OSTEOARTHRITIS/*metabolism; PROLINE/*metabolism; RABBITS; TIME FACTORS
CTG: | TIER; KNORPEL, GELENK-/*Stoffwechsel; KOLLAGEN/Analyse; KOLLAGEN/*Biosynthese; KRANKHEITSMODELLE, TIER; WEIBLICH; GALACTOSAMIN/Stoffwechsel; GLUCOSAMIN/Stoffwechsel; HYDROXYPROLIN/*Stoffwechsel; KNIEGELENK/Stoffwechsel; MOLEKÜLKONFORMATION; OSTEOARTHROSE/*Stoffwechsel; PROLIN/*Stoffwechsel; KANINCHEN; ZEITFAKTOREN
TE: | Proline/147-85-3; Glucosamine/3416-24-8; Hydroxyproline/51-35-4; Galactosamine/7535-00-4; Collagen/9007-34-5
CR: | 147-85-3; 3416-24-8; 51-35-4; 7535-00-4; 9007-34-5
AB: | Measurements of uptake in vivo of 3H-proline into 3H-hydroxyproline demonstrate that cartilage surfaces in rabbit knees with surgically induced osteoarthrosis (up to 3 months after operation) incorporated 2 to 5 times more activity into collagen than cartilage of control knees. The high uptake indicates that collagen synthesis was stimulated severalfold. In the lateral compartment of the experimental knee, which did not develop lesions, the 3H-proline metabolism was also stimulated, but this reaction subsided after 3 months. In the medial compartment, where the focal lesions developed, the stimulation continued. The newly made collagen was predominantly Type II; no evidence was found for a significant production of Type I collagen, even in the focal lesion on the medial tibial plateau more than a year after surgery. By radiochemical labelling with 3H-glucosamine,, an increase in the ratio of 3H-galactosamine to 3H-glucosamine was detected in all cartilage surfaces at intervals of 2-5 weeks after surgery. The increase was associated with the transient synovitis before lesions appeared, but not later. The observations suggest that synovitis and mechanical stresses are both important in inducing osteoarthrotic lesions.

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