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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/194 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME12757126
PMID: | 12757126
LR: | 20061213
CED: | 20030521
DCO: | 20040206
Autoren: | Zhang X; Ma Y; Liu H; De Sa PF; Brown PR; Dain JA
Titel: | Capillary electrophoresis separation of autocondensation glycation products of glucosamine.
Quelle: | Journal of capillary electrophoresis and microchip technology; VOL: 8 (1-2); p. 33-7 /2003 Jan-Apr/
PM: | Print
SU: | IM
Sprache: | English
CY: | United States
JID: | 101294946
Institution: | Department of Chemistry, University of Rhode Island, Kingston, RI 02881, USA.
DT: | Journal Article
Schlagwörter
CT: | ELECTROPHORESIS, CAPILLARY/*methods; GALACTOSAMINE/metabolism; GLUCOSAMINE/*metabolism; GLYCOSYLATION END PRODUCTS, ADVANCED/*isolation & purification; HEXOSAMINES/metabolism; SPECTRUM ANALYSIS
CTG: | ELEKTROPHORESE, KAPILLAR-/*Methoden; GALACTOSAMIN/Stoffwechsel; GLUCOSAMIN/*Stoffwechsel; GLYCOSYLIERUNGSENDPRODUKTE, FORTGESCHRITTENE/*Isolierung & Reinigung; HEXOSAMINE/Stoffwechsel; SPEKTRALANALYSE
TE: | Glycosylation End Products, Advanced; Hexosamines; mannosamine/2636-92-2; Glucosamine/3416-24-8; Galactosamine/7535-00-4
CR: | 2636-92-2; 3416-24-8; 7535-00-4
AB: | Glucosamine nonenzymatically forms autocondensation glycation products under physiological conditions. Many studies have reported the effectiveness of oral doses of glucosamine alone or in combination with the galactosamine containing chondroitin in treating osteoarthritis. However, none of these studies has considered whether it is the glucosamine itself and/or one or more of its autocondensation products that exert this effect. A capillary electrophoresis method was developed to monitor the nonenzymatic formation of autocondensation glycation products of glucosamine, galactosamine, and mannosamine under physiological conditions. Major components were detected and separated by CE with a UV detector. The effects of concentration and incubation time on product species were determined. The method described is simple, rapid, and effective.

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