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ND: | ME16999714
PMID: | 16999714
CED: | 20060926
DCO: | 20061219
Autoren: | Distler J; Anguelouch A
Titel: | Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis.
Quelle: | Journal of the American Academy of Nurse Practitioners; VOL: 18 (10); p. 487-93 /200610/
PM: | Print
SU: | N
Sprache: | English
CY: | United States
JID: | 8916634
ISSN: | 1041-2972
CO: | JANPEB
Institution: | Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, Maryland, USA. distler@son.umaryland.edu
DT: | Journal Article; Review
RN: | 27
Schlagwörter
CT: | CHONDROITIN/*therapeutic use; DRUG COMBINATIONS; DRUGS, NON-PRESCRIPTION/therapeutic use; EVIDENCE-BASED MEDICINE/*; GLUCOSAMINE/*therapeutic use; HEALTH SERVICES NEEDS AND DEMAND; HUMANS; META-ANALYSIS; OSTEOARTHRITIS/complications; OSTEOARTHRITIS/*drug therapy; PAIN/etiology; PAIN/prevention & control; PATIENT EDUCATION; PRACTICE GUIDELINES; PRIMARY HEALTH CARE; RANDOMIZED CONTROLLED TRIALS; RESEARCH DESIGN; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME
CTG: | CHONDROITIN/*therapeutische Anwendung; ARZNEIMITTELKOMBINATIONSPRÄPARATE; ARZNEIMITTEL, NICHT VERSCHREIBUNGSPFLICHTIGE/therapeutische Anwendung; GUTACHTENBASIERTE MEDIZIN/*; GLUCOSAMIN/*therapeutische Anwendung; GESUNDHEITSDIENSTE, ERFORDERNISSE UND ANFORDERUNGEN; MENSCH; METAANALYSE; OSTEOARTHROSE/Komplikationen; OSTEOARTHROSE/*Arzneimitteltherapie; SCHMERZEN/Ätiologie; SCHMERZEN/Verhütung & Bekämpfung; PATIENTENSCHULUNG; KLINISCHE RICHTLINIEN; MEDIZINISCHE GRUNDVERSORGUNG; RANDOMISIERTE KONTROLLIERTE STUDIEN; FORSCHUNGSDESIGN; SCHWEREGRADINDEX EINER KRANKHEIT; BEHANDLUNGSERGEBNIS
TE: | Drug Combinations; Drugs, Non-Prescription; Glucosamine/3416-24-8; Chondroitin/9007-27-6
CR: | 3416-24-8; 9007-27-6
AB: | PURPOSE: To evaluate past and current evidence from randomized controlled trials on the efficacy of glucosamine sulfate (GS), glucosamine hydrochloride (GH), and chondroitin sulfate (CS) for the treatment of osteoarthritis (OA). DATA SOURCES: An extensive review of four meta-analyses and a review of the findings of the recently published Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) funded by the National Institutes of Health. FINDINGS: Review of previous studies on the efficacy of GS, GH, and CS in the treatment of OA showed inconclusive results because of weak research design. The GAIT attempted to provide clarity on the use of GH and CS in treating knee pain from OA by using a rigorous research design to elicit cause and effect. The GAIT results showed that GH and CS were not effective in reducing knee pain in the study group overall; however, these may be effective in combination for patients with moderate-to-severe knee pain. IMPLICATIONS FOR PRACTICE: There is now clinical evidence indicating that recommending GS, GH, and CS for the treatment of mild knee pain from OA is ineffective. Further research needs to be done to identify specific characteristics in patients that results in a positive response. Until the findings of the GAIT undergo further peer review, the results of the research needs to be interpreted with caution.

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