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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME12749749
PMID: | 12749749
LR: | 20041117
CED: | 20030516
DCO: | 20030916
Autoren: | Walker-Bone K
Titel: | 'Natural remedies' in the treatment of osteoarthritis.
Quelle: | Drugs & aging; VOL: 20 (7); p. 517-26 /2003/
PM: | Print
SU: | IM
Sprache: | English
CY: | New Zealand
JID: | 9102074
ISSN: | 1170-229X
CO: | DRAGE6
Institution: | Medical Research Council Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK. kwb@mrc.soton.ac.uk
DT: | Journal Article; Review
RN: | 64
Schlagwörter
CT: | CLINICAL TRIALS; GLUCOSAMINE/*therapeutic use; HUMANS; OSTEOARTHRITIS/drug therapy; OSTEOARTHRITIS/*therapy; PERSEA/*; PHYTOTHERAPY; PLANT EXTRACTS/*therapeutic use; PLANT PREPARATIONS/*therapeutic use; REPRODUCIBILITY OF RESULTS
CTG: | KLINISCHE STUDIEN; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; OSTEOARTHROSE/Arzneimitteltherapie; OSTEOARTHROSE/*Therapie; PERSEA/*; PHYTOTHERAPIE; PFLANZENEXTRAKTE/*therapeutische Anwendung; PFLANZENZUBEREITUNGEN/*therapeutische Anwendung; REPRODUZIERBARKEIT, ERGEBNIS-
TE: | Plant Extracts; Plant Preparations; Glucosamine/3416-24-8
CR: | 3416-24-8
AB: | Osteoarthritis (OA) is a common, chronic and painful condition. It is the most common of all rheumatic disorders and is destined to become one of the most prevalent and costly diseases in our society. The conventional therapeutic options employed in the management of OA are simple analgesics and NSAIDs, but these options frequently produce sub-optimal benefit and are associated with an adverse-safety profile. Unsurprisingly patients are looking to alternative and complementary medicine. The aim of this article was to review the available literature on the effectiveness and safety of 'natural remedies' for the treatment of OA. Computerised literature searches were carried out for systematic reviews and randomised controlled trials examining the role of 'natural remedies' in the treatment of OA. There have been few randomised controlled trials of 'natural remedies' that have satisfied the internationally agreed standards. There was, however, evidence of efficacy for glucosamine, chondroitin sulfate and possibly avocado/soybean unsaponifiables for the symptomatic relief of OA. To date, it is not established whether any of the 'natural remedies' are capable of chondroprotection. Even if 'natural remedies' are only modestly effective, they are widely available and well tolerated, suggesting that they may play a significant role in the management of OA in the elderly.

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