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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/398 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME00144463
PMID: | 144463
LR: | 20041117
CED: | 19771229
DCO: | 19771229
Autoren: | Sweet MB; Thonar EJ; Immelman AR; Solomon L
Titel: | Biochemical changes in progressive osteoarthrosis.
Quelle: | Annals of the rheumatic diseases; VOL: 36 (5); p. 387-98 /197710/
PM: | Print
SU: | IM
Sprache: | English
CY: | ENGLAND
JID: | 0372355
ISSN: | 0003-4967
CO: | ARDIAO
DT: | Journal Article
Schlagwörter
CT: | CARTILAGE, ARTICULAR/analysis; CARTILAGE, ARTICULAR/*metabolism; FEMUR HEAD; GALACTOSAMINE/analysis; GLUCOSAMINE/analysis; GLYCOSAMINOGLYCANS/analysis; HUMANS; MIDDLE AGED; OSTEOARTHRITIS/*metabolism; PROTEOGLYCANS/analysis
CTG: | KNORPEL, GELENK-/Analyse; KNORPEL, GELENK-/*Stoffwechsel; FEMURKOPF; GALACTOSAMIN/Analyse; GLUCOSAMIN/Analyse; GLYCOSAMINO-GLYCANE/Analyse; MENSCH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE/*Stoffwechsel; PROTEOGLYCANE/Analyse
TE: | Glycosaminoglycans; Proteoglycans; Glucosamine/3416-24-8; Galactosamine/7535-00-4
CR: | 3416-24-8; 7535-00-4
AB: | Quantitative and qualitative variations in glycosaminoglycan content were studied in fibrillated, intact, and osteophytic cartilage of the human femoral head in osteoarthrosis. Total glycosaminoglycan content was reduced in fibrillated, unchanged in intact, and raised in osteophytic cartilage. In fibrillated and osteophytic cartilage the ratio of chondroitin sulphate to keratan sulphate was high and therefore resembled immature cartilage. Hyaluronic acid was present in reduced amount in all osteoarthrotic material. Proportionally more proteoglycans were extractable by 0-15 M NaCl and 4 M guanidinium chloride from the diseased cartilage than from normal cartilage, and all proteoglycans irrespective of buoyant density were carbohydrate deficient. It is postulated that the changes described are compatible with collagen and matrix disruption due to focal overloading and the general attempt at repair.

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