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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/72 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME16427582
PMID: | 16427582
CED: | 20060123
DCO: | 20060518
Autoren: | Goodrich LR; Nixon AJ
Titel: | Medical treatment of osteoarthritis in the horse - a review.
Quelle: | Veterinary journal (London, England : 1997); VOL: 171 (1); p. 51-69 /200601/
PM: | Print
SU: | IM
Sprache: | English
CY: | England
JID: | 9706281
ISSN: | 1090-0233
Institution: | Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA. lrg7@cornell.edu
DT: | Journal Article; Review
RN: | 173
Schlagwörter
CT: | ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/administration & dosage; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/adverse effects; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/*therapeutic use; CARTILAGE, ARTICULAR/drug effects; CARTILAGE, ARTICULAR/*pathology; GLUCOSAMINE/therapeutic use; HORSE DISEASES/*drug therapy; HORSE DISEASES/pathology; HORSES; INJECTIONS, INTRA-ARTERIAL/veterinary; JOINT DISEASES/drug therapy; JOINT DISEASES/pathology; JOINT DISEASES/*veterinary; OSTEOARTHRITIS/drug therapy; OSTEOARTHRITIS/pathology; OSTEOARTHRITIS/*veterinary; STEROIDS/administration & dosage; STEROIDS/adverse effects; STEROIDS/*therapeutic use; TREATMENT OUTCOME
CTG: | TIER; ANTIPHLOGISTIKA, NICHTSTEROIDALE/Verabreichung & Dosierung; ANTIPHLOGISTIKA, NICHTSTEROIDALE/unerwünschte Nebenwirkungen; ANTIPHLOGISTIKA, NICHTSTEROIDALE/*therapeutische Anwendung; KNORPEL, GELENK-/Arzneimittelwirkungen; KNORPEL, GELENK-/*Pathologie; GLUCOSAMIN/therapeutische Anwendung; PFERDEKRANKHEITEN/*Arzneimitteltherapie; PFERDEKRANKHEITEN/Pathologie; PFERDE; INJEKTIONEN, INTRAARTERIELLE/Veterinärmedizin; GELENKKRANKHEITEN/Arzneimitteltherapie; GELENKKRANKHEITEN/Pathologie; GELENKKRANKHEITEN/*Veterinärmedizin; OSTEOARTHROSE/Arzneimitteltherapie; OSTEOARTHROSE/Pathologie; OSTEOARTHROSE/*Veterinärmedizin; STEROIDE/Verabreichung & Dosierung; STEROIDE/unerwünschte Nebenwirkungen; STEROIDE/*therapeutische Anwendung; BEHANDLUNGSERGEBNIS
TE: | Anti-Inflammatory Agents, Non-Steroidal; Steroids; Glucosamine/3416-24-8
CR: | 3416-24-8
NOTE: | Comment in: Vet J. 2006 Jan;171(1):9-10; Ref.PMID: 16427575
AB: | The medical treatment of osteoarthritis (OA) in the horse is one of the most utilized therapeutic regimens in the equine practice. It is important to understand the anatomy of synovial joints and the pathophysiology of the disease process to treat OA adequately. Once a thorough understanding of the disease process is comprehended the proper combination of systemic nonsteroidal anti-inflammatory drugs (NSAIDs), intraarticular steroids, viscosupplementation and chondroprotectants can be used to treat the disease and inhibit further progression of degenerative changes to the cartilage surface. The equine practitioner is faced with many choices for controlling inflammation in OA. This review presents the background and appropriate uses of various NSAIDs such as phenylbutazone, flunixin meglumine, ketoprofen, naproxen, and carprofen as well as their associated toxicities. Various steroid formulations exist for intraarticular (IA) administration and much has been learned in the past decade regarding correct dosage, frequency of administrations, indications and toxicity. This review presents IA steroids and their indications in addition to various chondroprotective drugs that also exist to control inflammation and provide viscosupplementation. Data are also given on disease modifying OA drugs such as glucosamine and chondroitin sulphate that have more recently become available to the equine practitioner.

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