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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME11716368
PMID: | 11716368
LR: | 20061115
CED: | 20011121
DCO: | 20020509
Autoren: | Echard BW; Talpur NA; Funk KA; Bagchi D; Preuss HG
Titel: | Effects of oral glucosamine and chondroitin sulfate alone and in combination on the metabolism of SHR and SD rats.
Quelle: | Molecular and cellular biochemistry; VOL: 225 (1-); p. 85-91 /200109/
PM: | Print
SU: | IM
Sprache: | English
CY: | Netherlands
JID: | 0364456
ISSN: | 0300-8177
CO: | MCBIB8
Institution: | Department of Physiology and Biophysics, Georgetown University Medical Center Washington, DC 20007, USA.
DT: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE/analysis; BLOOD PRESSURE/drug effects; BODY WEIGHT/drug effects; CHONDROITIN SULFATES/administration & dosage; CHONDROITIN SULFATES/*pharmacology; GLUCOSAMINE/administration & dosage; GLUCOSAMINE/*pharmacology; GLUCOSE/metabolism; HYPERTENSION/*blood; HYPERTENSION/pathology; HYPERTENSION/physiopathology; INSULIN RESISTANCE; MALE; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; TIME FACTORS
CTG: | APPLIKATION, ORALE; TIER; BLUTGLUCOSE/Analyse; BLUTDRUCK/Arzneimittelwirkungen; KÖRPERGEWICHT/Arzneimittelwirkungen; CHONDROITINSULFATE/Verabreichung & Dosierung; CHONDROITINSULFATE/*Pharmakologie; GLUCOSAMIN/Verabreichung & Dosierung; GLUCOSAMIN/*Pharmakologie; GLUCOSE/Stoffwechsel; HYPERTONIE/*Blut; HYPERTONIE/Pathologie; HYPERTONIE/Pathophysiologie; INSULINRESISTENZ; MÄNNLICH; RATTUS; RATTEN, INZUCHTSTAMM SHR-; RATTEN, SPRAGUE-DAWLEY-; ZEITFAKTOREN
TE: | Blood Glucose; Glucosamine/3416-24-8; Glucose/50-99-7; Chondroitin Sulfates/9007-28-7
CR: | 3416-24-8; 50-99-7; 9007-28-7
AB: | Glucosamine (G), often combined with chondroitin sulfate (CS), is a popular natural supplement used widely to treat osteoarthritis. However, use of glucosamine has been linked to development of insulin resistance. To assess the association between glucosamine and insulin resistance more closely, we challenged two rat strains highly sensitive to sugar-induced insulin resistance-Sprague-Dawley (SD) and Spontaneously Hypertensive (SHR) rats. Since elevations of systolic blood pressure (SBP) have been found to be an early and highly sensitive sign of insulin resistance in these two rat strains, we used this parameter as our primary endpoint. Four groups of both rat strains received either no agent (control), G, CS, or a combination of both for 9 weeks. The intake of each agent was calculated to be approximately 3-7 times comparable to human dose. Throughout the study, SBP of both strains consuming the two ingredients alone and in combination were not elevated. Rather, they were significantly lower than control, contrary to what is found in glucose-induced insulin resistance in rats. Over the study period, body weights of the four groups of SD and SHR did not vary significantly. Furthermore, no consistent trends in circulating glucose concentrations were found among the four different groups in the two strains after oral challenge with glucose. Finally, no significant histological differences were found in hearts, kidneys, and livers among the various groups of SHR and SD. From the above result, we conclude that glucosamine and chondroitin sulfate given alone or together do not produce insulin resistance or other related perturbations in two rat strains highly sensitive to sugar-induced insulin resistance.

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