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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME11934964
PMID: | 11934964
LR: | 20061115
CED: | 20020405
DCO: | 20020604
Autoren: | Hughes R; Carr A
Titel: | A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee.
Quelle: | Rheumatology (Oxford, England); VOL: 41 (3); p. 279-84 /200203/
PM: | Print
SU: | AIM IM
Sprache: | English
CY: | England
JID: | 100883501
ISSN: | 1462-0324
CO: | RUMAFK
Institution: | St Peter's Hospital, Chertsey, Surrey, UK.
DT: | Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ADULT; ANALGESICS/*administration & dosage; DIETARY SUPPLEMENTS/*; DOUBLE-BLIND METHOD; FEMALE; GLUCOSAMINE/*administration & dosage; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE/*drug therapy; OSTEOARTHRITIS, KNEE/physiopathology; PAIN/*prevention & control; PAIN MEASUREMENT; PLACEBOS; TREATMENT OUTCOME
CTG: | ERWACHSENER; ANALGETIKA/*Verabreichung & Dosierung; NAHRUNGSERGÄNZUNGSMITTEL/*; DOPPELBLINDMETHODE; WEIBLICH; GLUCOSAMIN/*Verabreichung & Dosierung; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; OSTEOARTHROSE, KNIE/Pathophysiologie; SCHMERZEN/*Verhütung & Bekämpfung; SCHMERZMESSUNG; PLAZEBOS; BEHANDLUNGSERGEBNIS
TE: | Analgesics; Placebos; Glucosamine/3416-24-8
CR: | 3416-24-8
AB: | OBJECTIVES: A randomized, placebo-controlled, double-blind trial of the relative effectiveness of glucosamine sulphate and placebo in managing pain in osteoarthritis (OA) of the knee. METHODS: Eighty patients with OA of the knee were recruited from a rheumatology out-patient clinic and received either glucosamine sulphate 1500 mg daily for 6 months or dummy placebo. The primary outcome measure was patients' global assessment of pain in the affected knee. RESULTS: Area under the curve analysis for the primary outcome measure showed no difference between placebo and glucosamine [mean difference 0.15 mm, 95% confidence interval (CI) -8.78 to 9.07]. The placebo response was 33%. There was a statistically significant difference between groups in knee flexion (mean difference 13 degrees, 95% CI -23.13 to -1.97), but this difference was small and could have been due to measurement error. CONCLUSIONS: As a symptom modifier in OA patients with a wide range of pain severities, glucosamine sulphate was no more effective than placebo.

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