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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/331 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME10050562
PMID: | 10050562
LR: | 20061115
CED: | 19990311
DCO: | 19990311
Autoren: | Leffler CT; Philippi AF; Leffler SG; Mosure JC; Kim PD
Titel: | Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study.
Quelle: | Military medicine; VOL: 164 (2); p. 85-91 /199902/
PM: | Print
SU: | IM
Sprache: | English
CY: | UNITED STATES
JID: | 2984771R
ISSN: | 0026-4075
CO: | MMEDA9
Institution: | Medical Department, Naval Special Warfare Group Two, Naval Amphibious Base Little Creek, Norfolk, VA 23521, USA. occdr@aol.com
DT: | Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ACTIVITIES OF DAILY LIVING; ADULT; ASCORBIC ACID/*therapeutic use; CHONDROITIN SULFATES/*therapeutic use; CHRONIC DISEASE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; GLUCOSAMINE/*therapeutic use; HUMANS; LUMBAR VERTEBRAE/*; MALE; MANGANESE COMPOUNDS/*therapeutic use; MIDDLE AGED; MILITARY PERSONNEL/*; NAVAL MEDICINE; OSTEOARTHRITIS/*drug therapy; OSTEOARTHRITIS/radiography; OSTEOARTHRITIS, KNEE/*drug therapy; OSTEOARTHRITIS, KNEE/radiography; PAIN/etiology; PILOT PROJECTS; QUESTIONNAIRES; RUNNING
CTG: | AKTIVITÄTEN DES TÄGLICHEN LEBENS; ERWACHSENER; ASCORBINSÄURE/*therapeutische Anwendung; CHONDROITINSULFATE/*therapeutische Anwendung; CHRONISCHE KRANKHEIT; CROSS-OVER-STUDIEN; DOPPELBLINDMETHODE; ARZNEIMITTELKOMBINATIONSPRÄPARATE; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; LENDENWIRBEL/*; MÄNNLICH; MANGANVERBINDUNGEN/*therapeutische Anwendung; MENSCHEN IM MITTLEREN LEBENSALTER; MILITÄRPERSONAL/*; SCHIFFAHRTSMEDIZIN; OSTEOARTHROSE/*Arzneimitteltherapie; OSTEOARTHROSE/Röntgenuntersuchung; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; OSTEOARTHROSE, KNIE/Röntgenuntersuchung; SCHMERZEN/Ätiologie; PILOTPROJEKTE; FRAGEBOGEN; RENNEN
TE: | Drug Combinations; Manganese Compounds; Glucosamine/3416-24-8; Ascorbic Acid/50-81-7; Chondroitin Sulfates/9007-28-7
CR: | 3416-24-8; 50-81-7; 9007-28-7
AB: | OBJECTIVE: A 16-week randomized, double-blind, placebo-controlled crossover trial of a combination of glucosamine HCl (1,500 mg/day), chondroitin sulfate (1,200 mg/day), and manganese ascorbate (228 mg/day) in degenerative joint disease (DJD) of the knee or low back was conducted. METHODS: Thirty-four males from the U.S. Navy diving and special warfare community with chronic pain and radiographic DJD of the knee or low back were randomized. A summary disease score incorporated results of pain and functional questionnaires, physical examination scores, and running times. Changes were presented as a percentage of the patient's average score. RESULTS: Knee osteoarthritis symptoms were relieved as demonstrated by the summary disease score (-16.3%; p = 0.05), patient assessment of treatment effect (p = 0.02), visual analog scale for pain recorded at clinic visits (-26.6%; p = 0.05) and in a diary (-28.6%; p = 0.02), and physical examination score (-43.3%; p = 0.01). Running times did not change. The study neither demonstrated, nor excluded, a benefit for spinal DJD. Side effect frequency was similar to that at baseline. There were no hematologic effects. CONCLUSIONS: The combination therapy relieves symptoms of knee osteoarthritis. A larger data set is needed to determine the value of this therapy for spinal DJD. Short-term combination therapy appears safe in this setting.

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