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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME11904551
PMID: | 11904551
LR: | 20061115
CED: | 20020320
DCO: | 20020625
Autoren: | Ruane R; Griffiths P
Titel: | Glucosamine therapy compared to ibuprofen for joint pain.
Quelle: | British journal of community nursing; VOL: 7 (3); p. 148-52 /200203/
PM: | Print
SU: | N
Sprache: | English
CY: | England
JID: | 9815827
ISSN: | 1462-4753
Institution: | Primary Care and Community Pharmacy, King's College London.
DT: | Comparative Study; Journal Article; Review
RN: | 14
Schlagwörter
CT: | ARTHRALGIA/*drug therapy; GLUCOSAMINE/*therapeutic use; HUMANS; IBUPROFEN/*therapeutic use; OSTEOARTHRITIS/drug therapy; TREATMENT OUTCOME
CTG: | ARTHRALGIE/*Arzneimitteltherapie; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; IBUPROFEN/*therapeutische Anwendung; OSTEOARTHROSE/Arzneimitteltherapie; BEHANDLUNGSERGEBNIS
TE: | Ibuprofen/15687-27-1; Glucosamine/3416-24-8
CR: | 15687-27-1; 3416-24-8
AB: | To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken. The population was adult patients diagnosed with osteoarthritis at any site. The outcome was arthritic pain reduction. Searches on Medline, Embase, AMED, the Cochrane Library and the Merck index identified four trials. Of these, two studies were obtainable and were included in the review. Both compared 1.2 g ibuprofen daily with 1.5 g glucosamine sulphate daily, in three divided doses. The combined number of participants in the studies was 218. The results of these studies showed glucosamine to be of similar efficacy to ibuprofen. The conclusion is that glucosamine is effective in relieving joint pain associated with osteoarthritis. Glucosamine's pain-relieving effects may be due to its cartilage-rebuilding properties; these disease-modifying effects are not seen with simple analgesics and are of particular benefit. In practice glucosamine can be used as an alternative to anti-inflammatory drugs and analgesics or as a useful adjunct to standard analgesic therapy.

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