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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME12596539
PMID: | 12596539
LR: | 20061115
CED: | 20030224
DCO: | 20030324
Autoren: | Zupanets IA; Bezdetko NV; Dedukh NV; Otrishko IA
Titel: | Eksperimental'noe izuchenie vliianiia gliukozamina gidrokhlorida na metabolicheskie i reparativnye protsessy v soedinitel'notkannykh strukturakh. Experimental study of the effect of glucosamine hydrochloride on metabolic and repair processes in connective tissue structures
Quelle: | Eksperimental'naia i klinicheskaia farmakologiia; VOL: 65 (6); p. 67-9 /2002 Nov-Dec/
PM: | Print
SU: | IM
Sprache: | Russian
CY: | Russia
JID: | 9215981
ISSN: | 0869-2092
CO: | EKFAE9
Institution: | Clinical Pharmacy Department, National Pharmaceutical Academy of Ukraine, ul. Pushkinskaya 53, Kharkov 61002, Ukraine.
DT: | English Abstract; Journal Article
Schlagwörter
CT: | ANIMALS; CONNECTIVE TISSUE/*injuries; CONNECTIVE TISSUE/*metabolism; CORNEA/metabolism; GLUCOSAMINE/*pharmacology; GLYCOSAMINOGLYCANS/metabolism; KERATITIS/etiology; KERATITIS/metabolism; OSTEOARTHRITIS, HIP/etiology; OSTEOARTHRITIS, HIP/metabolism; RABBITS; RATS; WOUND HEALING/*drug effects
CTG: | TIER; BINDEGEWEBE/*Verletzungen; BINDEGEWEBE/*Stoffwechsel; KORNEA/Stoffwechsel; GLUCOSAMIN/*Pharmakologie; GLYCOSAMINO-GLYCANE/Stoffwechsel; KERATITIS/Ätiologie; KERATITIS/Stoffwechsel; OSTEOARTHROSE, HÜFT-/Ätiologie; OSTEOARTHROSE, HÜFT-/Stoffwechsel; KANINCHEN; RATTUS; WUNDHEILUNG/*Arzneimittelwirkungen
TE: | Glycosaminoglycans; Glucosamine/3416-24-8
CR: | 3416-24-8
AB: | The effects of glucosamine hydrochloride on the metabolic and repair processes were studied on a model of post-traumatic osteoarthrosis in the articular cartilage and on a model of post-traumatic keratitis in the cornea. The administration of glucosamine hydrochloride stimulated repair and favored inhibition of dystrophic post-traumatic processes in the connective-tissue structures. It is suggested that a probable mechanism of the drug action consists in stimulation of the synthesis of glucosaminoglycanes and collagen.

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