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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/391 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME07002479
PMID: | 7002479
LR: | 20041117
CED: | 19810224
DCO: | 19810224
Autoren: | Pujalte JM; Llavore EP; Ylescupidez FR
Titel: | Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis.
Quelle: | Current medical research and opinion; VOL: 7 (2); p. 110-14 /1980/
PM: | Print
SU: | IM
Sprache: | English
CY: | ENGLAND
JID: | 0351014
ISSN: | 0300-7995
CO: | CMROCX
DT: | Clinical Trial; Journal Article; Randomized Controlled Trial
Schlagwörter
CT: | AGED; CLINICAL TRIALS; DOUBLE-BLIND METHOD; DRUG TOLERANCE; FEMALE; GLUCOSAMINE/*therapeutic use; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS/*drug therapy; PROSPECTIVE STUDIES
CTG: | ALTE MENSCHEN; KLINISCHE STUDIEN; DOPPELBLINDMETHODE; ARZNEIMITTELTOLERANZ; WEIBLICH; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE/*Arzneimitteltherapie; PROSPEKTIVE STUDIEN
TE: | Glucosamine/3416-24-8
CR: | 3416-24-8
AB: | The efficacy and tolerance of oral glucosamine sulphate were tested against placebo in a prospective double-blind trial in 20 out-patients with established osteoarthrosis. Two capsules of either glucosaminene sulphate (250 mg) or placebo were administered 3-times daily over a period of 6 to 8 weeks. Articular pain, joint tenderness and restricted movement were semi-quantitatively scored 1 to 4 every 3 days, and individually averaged over the treatment period (overall composite score). Possible side-reactions were similarly scored upon positive questioning of the patients. Haematology, erythrocyte sedimentation rate, urine analysis and X-rays were recorded before and after treatment. Significant alleviation of symptoms was associated with the use of the active drug at the prescribed dose. Similarly, patients given glucosamine sulphate experienced earlier alleviation of symptoms compared with those who had placebo. The use of glucosamine sulphate also resulted in a significantly larger proportion of patients who experienced lessening or disappearance of symptoms within the trial period. No adverse reactions were reported by the patients treated with glucosamine, and no variation in laboratory tests was recorded.

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