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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME09080302
PMID: | 9080302
LR: | 20061115
CED: | 19970626
DCO: | 19970626
Autoren: | Bond A; Alavi A; Axford JS; Bourke BE; Bruckner FE; Kerr MA; Maxwell JD; Tweed KJ; Weldon MJ; Youinou P; Hay FC
Titel: | A detailed lectin analysis of IgG glycosylation, demonstrating disease specific changes in terminal galactose and N-acetylglucosamine.
Quelle: | Journal of autoimmunity; VOL: 10 (1); p. 77-85 /199702/
PM: | Print
SU: | IM
Sprache: | English
CY: | ENGLAND
JID: | 8812164
ISSN: | 0896-8411
CO: | JOAUEP
Institution: | Division of Immunology, St George's Hospital Medical School, London. a.bond@sghms.ac.uk
DT: | Journal Article; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ACETYLGLUCOSAMINE/*metabolism; ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID/immunology; ARTHRITIS, RHEUMATOID/metabolism; GALACTOSE/*metabolism; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN G/*metabolism; LECTINS/metabolism; MIDDLE AGED; OLIGOSACCHARIDES/metabolism; SJOGREN'S SYNDROME/immunology; SJOGREN'S SYNDROME/metabolism
CTG: | ACETYLGLUCOSAMIN/*Stoffwechsel; ERWACHSENER; ALTE MENSCHEN; ALTE MENSCHEN, 80 JAHRE UND ÄLTER; ARTHRITIS, RHEUMATOIDE/Immunologie; ARTHRITIS, RHEUMATOIDE/Stoffwechsel; GALACTOSE/*Stoffwechsel; GLYCOSYLIERUNG; MENSCH; IMMUNGLOBULIN G/*Stoffwechsel; LECTINE/Stoffwechsel; MENSCHEN IM MITTLEREN LEBENSALTER; OLIGOSACCHARIDE/Stoffwechsel; SJÖGREN-SYNDROM/Immunologie; SJÖGREN-SYNDROM/Stoffwechsel
TE: | Immunoglobulin G; Lectins; Oligosaccharides; Galactose/26566-61-0; Acetylglucosamine/7512-17-6
CR: | 26566-61-0; 7512-17-6
AB: | Serum IgG from rheumatoid arthritis patients contains a decreased number of oligosaccharide structures ending in galactose and thus there is an increase in N-acetylglucosamine as the terminal sugar, compared with healthy individuals. The relationship between these two sugars varies depending on the disease examined: IgG from patients with rheumatoid arthritis, juvenile onset chronic arthritis and Crohn's disease are at one extreme, and exhibit a reciprocal galactose:N-acetylglucosamine relationship, while Sjögren's syndrome and osteoarthritis IgG are at the other extreme, exhibiting a parallel increase in the expression of both galactose and N-acetylglucosamine. These results may occur as a consequence of more than one glycosylation site which is differentially glycosylated, but more likely by changes in the level of bisecting N-acetylglucosamine.

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