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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/387 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME07019929
PMID: | 7019929
LR: | 20041117
CED: | 19810925
DCO: | 19810925
Autoren: | D'Ambrosio E; Casa B; Bompani R; Scali G; Scali M
Titel: | Glucosamine sulphate: a controlled clinical investigation in arthrosis.
Quelle: | Pharmatherapeutica; VOL: 2 (8); p. 504-8 /1981/
PM: | Print
SU: | IM
Sprache: | English
CY: | ENGLAND
JID: | 7606274
ISSN: | 0308-051X
CO: | PHARDW
DT: | Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial
Schlagwörter
CT: | AGED; CLINICAL TRIALS; FEMALE; GLUCOSAMINE/adverse effects; GLUCOSAMINE/*therapeutic use; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS/*drug therapy
CTG: | ALTE MENSCHEN; KLINISCHE STUDIEN; WEIBLICH; GLUCOSAMIN/unerwünschte Nebenwirkungen; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE/*Arzneimitteltherapie
TE: | Glucosamine/3416-24-8
CR: | 3416-24-8
AB: | Efficacy and tolerance of a new preparation of pure glucosamine sulphate, in injectable and oral form, were investigated in 30 patients with osteoarthrosis. Two groups of in-patients with chronic degenerative articular disorders received daily for 7 days either 400 mg glucosamine sulphate or a piperazine/chlorbutanol combination by intravenous or intramuscular injection. During the 2 following weeks, the patients receiving glucosamine had oral glucosamine capsules (6 x 250 mg daily); the other group had placebo. Efficacy was tested by semi-quantitative scoring of pain at rest and during active and passive movements, as well as limitation of articular function, before and after 7 and 21 days of treatment. Patients were positively questioned daily for possible intolerance symptoms. Haematology, circulatory data and urine analysis were tested before and after treatment. During both initial parenteral treatments, each symptom significantly improved, but to a faster and greater extent in the group treated with glucosamine. During the maintenance period, a further improvement was recorded in the patients treated with glucosamine, whereas in those on placebo the symptom scores increased almost to the pre-treatment level. This was considered the major difference between basic therapy, such as with glucosamine, as purely symptomatic treatment. Clinical and biological tolerance were excellent with both treatments, and no definitely drug-related complaints were recorded. It is suggested that parenteral and/or oral treatment with pure glucosamine sulphate should be considered as basic therapy for the management of primary or secondary degenerative osteoarthrosis disorders.

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