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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/396 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME00429413
PMID: | 429413
LR: | 20061115
CED: | 19790611
DCO: | 19790611
Autoren: | Thompson RC Jr; Oegema TR Jr
Titel: | Metabolic activity of articular cartilage in osteoarthritis. An in vitro study.
Quelle: | The Journal of bone and joint surgery. American volume; VOL: 61 (3); p. 407-16 /197904/
PM: | Print
SU: | AIM IM
Sprache: | English
CY: | UNITED STATES
JID: | 0014030
ISSN: | 0021-9355
CO: | JBJSA3
DT: | In Vitro; Journal Article
Schlagwörter
CT: | AGED; AUTORADIOGRAPHY; CARTILAGE, ARTICULAR/*metabolism; CARTILAGE, ARTICULAR/pathology; CETYLPYRIDINIUM/diagnostic use; CHONDROITIN/*analogs & derivatives; CHONDROITIN SULFATES/analysis; CHONDROITIN SULFATES/*metabolism; CHROMATOGRAPHY, PAPER; DNA/analysis; DNA/*metabolism; DIALYSIS; FEMALE; FRACTIONAL PRECIPITATION; GALACTOSAMINE/analysis; GALACTOSAMINE/*metabolism; GLUCOSAMINE/analysis; GLUCOSAMINE/*metabolism; GLYCOSAMINOGLYCANS/analysis; GLYCOSAMINOGLYCANS/biosynthesis; GLYCOSAMINOGLYCANS/*metabolism; HEXOSAMINES/analysis; HEXOSAMINES/*metabolism; HEXURONIC ACIDS/analysis; HEXURONIC ACIDS/*metabolism; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS/*metabolism; OSTEOARTHRITIS/pathology; SPECTROPHOTOMETRY; SULFUR RADIOISOTOPES; URONIC ACIDS/*metabolism
CTG: | ALTE MENSCHEN; AUTORADIOGRAPHIE; KNORPEL, GELENK-/*Stoffwechsel; KNORPEL, GELENK-/Pathologie; CETYLPYRIDINIUM/diagnostische Verwendung; CHONDROITIN/*Analoge & Derivate; CHONDROITINSULFATE/Analyse; CHONDROITINSULFATE/*Stoffwechsel; CHROMATOGRAPHIE, PAPIER-; DNA/Analyse; DNA/*Stoffwechsel; DIALYSE; WEIBLICH; FRAKTIONIERTE PRÄZIPITATION; GALACTOSAMIN/Analyse; GALACTOSAMIN/*Stoffwechsel; GLUCOSAMIN/Analyse; GLUCOSAMIN/*Stoffwechsel; GLYCOSAMINO-GLYCANE/Analyse; GLYCOSAMINO-GLYCANE/Biosynthese; GLYCOSAMINO-GLYCANE/*Stoffwechsel; HEXOSAMINE/Analyse; HEXOSAMINE/*Stoffwechsel; HEXURONSÄUREN/Analyse; HEXURONSÄUREN/*Stoffwechsel; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE/*Stoffwechsel; OSTEOARTHROSE/Pathologie; SPEKTROPHOTOMETRIE; SCHWEFELRADIOISOTOPE; URONSÄUREN/*Stoffwechsel
TE: | Glycosaminoglycans; Hexosamines; Hexuronic Acids; Sulfur Radioisotopes; Uronic Acids; Glucosamine/3416-24-8; Galactosamine/7535-00-4; Cetylpyridinium/7773-52-6; Chondroitin/9007-27-6; Chondroitin Sulfates/9007-28-7; DNA/9007-49-2
CR: | 3416-24-8; 7535-00-4; 7773-52-6; 9007-27-6; 9007-28-7; 9007-49-2
AB: | Biochemical changes and in vitro rates of glycosaminoglycan synthesis were studied in thirty-seven samples of human articular cartilage from nineteen osteoarthritic and four normal control patients who were fifty to seventy-five years old. The samples were compared on the basis of histological grade of the arthritis, and subgroups based on the duration of disease, synovial pathological changes, joint studied, and sex were also compared. The osteoarthritic samples showed a progressive loss of glycosaminoglycans in the cartilage as the histological grade increased. In the early stages of the disease there was an increase in the chondroitin sulphate content as well as in the rate of glycosaminoglycan synthesis in several cases when the values for the osteoarthritic articular-cartilage samples were compared with those for the age-matched controls. In the late stages there was a progressive decrease in the rate of glycosaminoglycan synthesis and a relative decrease in chrondroitin sulphate synthesis compared with keratan sulphate synthesis, and these decreases were highly correlated with the histological grade.

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