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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME11922194
PMID: | 11922194
LR: | 20041117
CED: | 20020329
DCO: | 20020411
Autoren: | Bruyere O; Honore A; Rovati LC; Giacovelli G; Henrotin YE; Seidel L; Reginster JY
Titel: | Radiologic features poorly predict clinical outcomes in knee osteoarthritis.
Quelle: | Scandinavian journal of rheumatology; VOL: 31 (1); p. 13-6 /2002/
PM: | Print
SU: | IM
Sprache: | English
CY: | Norway
JID: | 0321213
ISSN: | 0300-9742
CO: | SJRHAT
Institution: | WHO Collaborating Center for Public Health Aspect of Osteoarticular Disorders, Liege, Belgium.
DT: | Clinical Trial; Journal Article; Randomized Controlled Trial
Schlagwörter
CT: | AGED; ARTHROGRAPHY/*methods; DISABILITY EVALUATION; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; GLUCOSAMINE/therapeutic use; HUMANS; KNEE JOINT/physiopathology; KNEE JOINT/*radiography; OSTEOARTHRITIS, KNEE/drug therapy; OSTEOARTHRITIS, KNEE/physiopathology; OSTEOARTHRITIS, KNEE/*radiography; PAIN MEASUREMENT; QUESTIONNAIRES; REPRODUCIBILITY OF RESULTS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME
CTG: | ALTE MENSCHEN; ARTHROGRAPHIE/*Methoden; INVALIDITÄTSBEURTEILUNG; KRANKHEITSPROGRESSION; DOPPELBLINDMETHODE; GLUCOSAMIN/therapeutische Anwendung; MENSCH; KNIEGELENK/Pathophysiologie; KNIEGELENK/*Röntgenuntersuchung; OSTEOARTHROSE, KNIE/Arzneimitteltherapie; OSTEOARTHROSE, KNIE/Pathophysiologie; OSTEOARTHROSE, KNIE/*Röntgenuntersuchung; SCHMERZMESSUNG; FRAGEBOGEN; REPRODUZIERBARKEIT, ERGEBNIS-; SCHWEREGRADINDEX EINER KRANKHEIT; BEHANDLUNGSERGEBNIS
TE: | Glucosamine/3416-24-8
CR: | 3416-24-8
AB: | OBJECTIVES: To assess the impact of radiographic severity and progression on pain and disability. METHODS: Measurements of mean joint space width (JSW), narrowest join space (NJS) point and assessment of symptoms by the WOMAC questionnaire were performed at baseline and after three years in 212 subjects over 50 years with primary knee OA. RESULTS: At baseline, JSW and NJS were not significantly correlated with the scores recorded for the WOMAC global index or its pain, stiffness or function subscales. A statistically significant correlation was observed between the joint space narrowing over three years and the changes observed in the pain subscale of the WOMAC during the same period. The three-year changes in the global WOMAC index in patients within the lowest and the highest quartiles of mean joint space width at baseline showed, in both cases, a statistically (p<0.05) significant favorable difference between patients treated with glucosamine sulphate and those having received placebo. CONCLUSION: Radiographic and clinical progressions of the disease are significantly associated but the clinical relevance of the association is questionable.

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