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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/256 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME11436179
PMID: | 11436179
LR: | 20061115
CED: | 20010703
DCO: | 20010802
Autoren: | Hoffer LJ; Kaplan LN; Hamadeh MJ; Grigoriu AC; Baron M
Titel: | Sulfate could mediate the therapeutic effect of glucosamine sulfate.
Quelle: | Metabolism: clinical and experimental; VOL: 50 (7); p. 767-70 /200107/
PM: | Print
SU: | IM
Sprache: | English
CY: | United States
JID: | 0375267
ISSN: | 0026-0495
CO: | METAAJ
Institution: | Lady Davis Institute for Medical Research and Division of Rheumatology, Sir Mortimer B. Jewish General Hospital, Montreal, Quebec, Canada.
DT: | Journal Article; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ACETAMINOPHEN/pharmacology; ADULT; ANALGESICS, NON-NARCOTIC/pharmacology; FEMALE; GLUCOSAMINE/administration & dosage; GLUCOSAMINE/antagonists & inhibitors; GLUCOSAMINE/*therapeutic use; HUMANS; MALE; SULFATES/blood; SULFATES/*metabolism; SYNOVIAL FLUID/metabolism
CTG: | ACETAMINOPHEN/Pharmakologie; ERWACHSENER; ANALGETIKA, NICHTNARKOTISCHE/Pharmakologie; WEIBLICH; GLUCOSAMIN/Verabreichung & Dosierung; GLUCOSAMIN/Antagonisten & Inhibitoren; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; MÄNNLICH; SULFATE/Blut; SULFATE/*Stoffwechsel; SYNOVIALFLÜSSIGKEIT/Stoffwechsel
TE: | Analgesics, Non-Narcotic; Sulfates; Acetaminophen/103-90-2; Glucosamine/3416-24-8
CR: | 103-90-2; 3416-24-8
AB: | Glucosamine sulfate is a controversial osteoarthritis remedy that is presumed to stimulate articular cartilage glycosaminoglycan synthesis by increasing glucosamine concentrations in the joint space. However, this is not plausible because even large oral doses of the product have no effect on serum glucosamine concentrations. We propose instead that sulfate could mediate the clinical benefit attributed to this treatment. Sulfate is required for glycosaminoglycan synthesis, and unlike glucosamine, its serum level can be modified by dietary and other factors. In this study, we tested whether oral glucosamine sulfate increases serum sulfate concentrations and whether the sulfate concentration in the synovial fluid reflects that in the serum. The serum sulfate concentration of 7 normal subjects was 331 +/- 21 micromol/L before ingestion of 1.0 g glucosamine sulfate and 375 +/- 17 micromol/L 3 hours after (P <.05). Serum sulfate concentrations decreased from 325 +/- 19 to 290 +/- 19 micromol/L when the same dose of glucosamine sulfate was ingested with 1.0 g of the analgesic drug acetaminophen, which is largely metabolized by sulfation (P <.05). Unlike glucosamine sulfate, oral sodium sulfate did not significantly increase the serum sulfate concentration. Synovial fluid and serum sulfate concentrations were closely similar when measured in 15 patients undergoing diagnostic needle aspiration of a knee effusion (r =.99, slope =.97, P <.0001). These results do not prove that glucosamine sulfate improves osteoarthritis, but considered with other data, they do provide a plausible biochemical mechanism for its reported beneficial effects. This hypothesis is clinically relevant because it predicts that nonsulfate salts of glucosamine will be ineffective and that renal function, diet, and concurrent acetaminophen therapy could confound clinical trials of this therapy. - CNOTE: Copyright 2001 by W.B. Saunders Company

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