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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME11281631
PMID: | 11281631
LR: | 20051116
CED: | 20010403
DCO: | 20010607
Autoren: | Brief AA; Maurer SG; Di Cesare PE
Titel: | Use of glucosamine and chondroitin sulfate in the management of osteoarthritis.
Quelle: | The Journal of the American Academy of Orthopaedic Surgeons; VOL: 9 (2); p. 71-8 /2001 Mar-Apr/
PM: | Print
SU: | IM
Sprache: | English
CY: | United States
JID: | 9417468
ISSN: | 1067-151X
Institution: | Department of Orthopaedic Surgery, New York University-Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA.
DT: | Journal Article; Review
RN: | 34
Schlagwörter
CT: | ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/therapeutic use; CARTILAGE, ARTICULAR/drug effects; CHONDROITIN SULFATES/pharmacology; CHONDROITIN SULFATES/*therapeutic use; CLINICAL TRIALS; GLUCOSAMINE/pharmacology; GLUCOSAMINE/*therapeutic use; HUMANS; IBUPROFEN/therapeutic use; OSTEOARTHRITIS/*drug therapy; TREATMENT OUTCOME
CTG: | ANTIPHLOGISTIKA, NICHTSTEROIDALE/therapeutische Anwendung; KNORPEL, GELENK-/Arzneimittelwirkungen; CHONDROITINSULFATE/Pharmakologie; CHONDROITINSULFATE/*therapeutische Anwendung; KLINISCHE STUDIEN; GLUCOSAMIN/Pharmakologie; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; IBUPROFEN/therapeutische Anwendung; OSTEOARTHROSE/*Arzneimitteltherapie; BEHANDLUNGSERGEBNIS
TE: | Anti-Inflammatory Agents, Non-Steroidal; Ibuprofen/15687-27-1; Glucosamine/3416-24-8; Chondroitin Sulfates/9007-28-7
CR: | 15687-27-1; 3416-24-8; 9007-28-7
NOTE: | Comment in: J Am Acad Orthop Surg. 2001 Sep-Oct;9(5):352-3; Ref.PMID: 11599524
AB: | The goals of osteoarthritis therapy are to decrease pain and to maintain or improve joint function. The pharmacologic treatment of this condition has included the use of aspirin, acetaminophen, and nonsteroidal anti-inflammatory drugs. More recently, numerous studies have investigated the potential role of chondroprotective agents in repairing articular cartilage and decelerating the degenerative process. The reports of limited clinical experience with two of these agents, glucosamine and chondroitin sulfate, as well as the accompanying publicity in the popular media, have generated controversy. Advocates of these alternative modalities cite reports of progressive and gradual decline of joint pain and tenderness, improved mobility, sustained improvement after drug withdrawal, and a lack of significant toxicity associated with short-term use of these agents. Critics point out that in the great majority of the relevant clinical trials, sample sizes were small and follow-up was short-term.

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