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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME11127967
PMID: | 11127967
LR: | 20051116
CED: | 20001213
DCO: | 20010215
Autoren: | de los Reyes GC; Koda RT; Lien EJ
Titel: | Glucosamine and chondroitin sulfates in the treatment of osteoarthritis: a survey.
Quelle: | Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques; VOL: 55; p. 81-103 /2000/
PM: | Print
SU: | IM
Sprache: | English
CY: | Switzerland
JID: | 1304021
ISSN: | 0071-786X
CO: | FAZMAE
Institution: | Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.
DT: | Journal Article; Review
RN: | 51
Schlagwörter
CT: | CHONDROITIN/adverse effects; CHONDROITIN/pharmacokinetics; CHONDROITIN/*therapeutic use; CLINICAL TRIALS; GLUCOSAMINE/adverse effects; GLUCOSAMINE/pharmacokinetics; GLUCOSAMINE/*therapeutic use; HUMANS; OSTEOARTHRITIS/*drug therapy
CTG: | CHONDROITIN/unerwünschte Nebenwirkungen; CHONDROITIN/Pharmakokinetik; CHONDROITIN/*therapeutische Anwendung; KLINISCHE STUDIEN; GLUCOSAMIN/unerwünschte Nebenwirkungen; GLUCOSAMIN/Pharmakokinetik; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; OSTEOARTHROSE/*Arzneimitteltherapie
TE: | Glucosamine/3416-24-8; Chondroitin/9007-27-6
CR: | 3416-24-8; 9007-27-6
AB: | For more than 30 years, non-steroidal anti-inflammatory drugs (NSAIDs) have been used as standards in the treatment of osteoarthritis (OA). Serious and often life-threatening adverse effects due to these agents are common. Clinical findings have revealed that glucosamine sulfate and chondroitin sulfate are effective and safer alternatives to alleviate symptoms of OA. Experimental evidence indicates that these compounds and their low molecular weight derivatives have a particular tropism for cartilage where they serve as substrates in the biosynthesis of component building blocks. This paper is a literature review of the chemistry, mechanism of action, pharmacokinetics, clinical efficacy and safety of these two nutraceuticals.

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