Dokumente
Suchschritt : FT=glucosamine AND FT=osteoarthritis
» Fenster schließen »

2/218 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME12374520
PMID: | 12374520
LR: | 20061115
CED: | 20021010
DCO: | 20021108
Autoren: | Pavelká K; Gatterová J; Olejarová M; Machacek S; Giacovelli G; Rovati LC
Titel: | Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.
Quelle: | Archives of internal medicine; VOL: 162 (18); p. 2113-23 /20021014/
PM: | Print
SU: | AIM IM
Sprache: | English
CY: | United States
JID: | 0372440
ISSN: | 0003-9926
CO: | AIMDAP
Institution: | Department of Medicine and Rheumatology, Charles University, Prague, Czech Republic. pavelka@revma.cz
DT: | Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ADMINISTRATION, ORAL; AGED; DIETARY SUPPLEMENTS/*; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; GLUCOSAMINE/*therapeutic use; HUMANS; KNEE JOINT/*drug effects; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE/complications; OSTEOARTHRITIS, KNEE/*drug therapy; OSTEOARTHRITIS, KNEE/*prevention & control; PAIN/etiology; PAIN/prevention & control; TREATMENT OUTCOME
CTG: | APPLIKATION, ORALE; ALTE MENSCHEN; NAHRUNGSERGÄNZUNGSMITTEL/*; KRANKHEITSPROGRESSION; DOPPELBLINDMETHODE; WEIBLICH; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; KNIEGELENK/*Arzneimittelwirkungen; LONGITUDINALSTUDIEN; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE, KNIE/Komplikationen; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; OSTEOARTHROSE, KNIE/*Verhütung & Bekämpfung; SCHMERZEN/Ätiologie; SCHMERZEN/Verhütung & Bekämpfung; BEHANDLUNGSERGEBNIS
TE: | Glucosamine/3416-24-8
CR: | 3416-24-8
AB: | BACKGROUND: Conventional symptomatic treatments for osteoarthritis do not favorably affect disease progression. The aim of this randomized, placebo-controlled trial was to determine whether long-term (3-year) treatment with glucosamine sulfate can modify the progression of joint structure and symptom changes in knee osteoarthritis, as previously suggested. METHODS: Two hundred two patients with knee osteoarthritis (using American College of Rheumatology criteria) were randomized to receive oral glucosamine sulfate, 1500 mg once a day, or placebo. Changes in radiographic minimum joint space width were measured in the medial compartment of the tibiofemoral joint, and symptoms were assessed using the algo-functional indexes of Lequesne and WOMAC (Western Ontario and McMaster Universities). RESULTS: Osteoarthritis was of mild to moderate severity at enrollment, with average joint space widths of slightly less than 4 mm and a Lequesne index score of less than 9 points. Progressive joint space narrowing with placebo use was -0.19 mm (95% confidence interval, -0.29 to -0.09 mm) after 3 years. Conversely, there was no average change with glucosamine sulfate use (0.04 mm; 95% confidence interval, -0.06 to 0.14 mm), with a significant difference between groups (P =.001). Fewer patients treated with glucosamine sulfate experienced predefined severe narrowings (>0.5 mm): 5% vs 14% (P =.05). Symptoms improved modestly with placebo use but as much as 20% to 25% with glucosamine sulfate use, with significant final differences on the Lequesne index and the WOMAC total index and pain, function, and stiffness subscales. Safety was good and without differences between groups. CONCLUSION: Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.

» Volltext »
» Fenster schließen »