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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME15883746
PMID: | 15883746
LR: | 20061115
CED: | 20050510
DCO: | 20050711
Autoren: | Hua J; Suguro S; Hirano S; Sakamoto K; Nagaoka I
Titel: | Preventive actions of a high dose of glucosamine on adjuvant arthritis in rats.
Quelle: | Inflammation research : official journal of the European Histamine Research Society ... [et al.]; VOL: 54 (3); p. 127-32 /200503/
PM: | Print
SU: | IM
Sprache: | English
CY: | Switzerland
JID: | 9508160
ISSN: | 1023-3830
CO: | INREFB
Institution: | Department of Host Defense and Biochemical Research, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
DT: | Journal Article; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ANIMALS; ANTI-INFLAMMATORY AGENTS/pharmacology; ARTHRITIS, EXPERIMENTAL/*prevention & control; ARTHRITIS, RHEUMATOID/*prevention & control; DINOPROSTONE/metabolism; DOSE-RESPONSE RELATIONSHIP, DRUG; FREUND'S ADJUVANT/pharmacology; GLUCOSAMINE/metabolism; GLUCOSAMINE/*pharmacology; INFLAMMATION; MALE; NITRIC OXIDE/metabolism; RATS; RATS, WISTAR; SYNOVIAL MEMBRANE/metabolism; TIME FACTORS
CTG: | TIER; ANTIPHLOGISTIKA/Pharmakologie; ARTHRITIS, EXPERIMENTELLE/*Verhütung & Bekämpfung; ARTHRITIS, RHEUMATOIDE/*Verhütung & Bekämpfung; DINOPROSTON/Stoffwechsel; DOSIS-WIRKUNGSBEZIEHUNG, ARZNEIMITTEL-; FREUND-ADJUVANS/Pharmakologie; GLUCOSAMIN/Stoffwechsel; GLUCOSAMIN/*Pharmakologie; ENTZÜNDUNG; MÄNNLICH; STICKSTOFFMONOXID/Stoffwechsel; RATTUS; RATTEN, WISTAR-; SYNOVIALMEMBRAN/Stoffwechsel; ZEITFAKTOREN
TE: | Anti-Inflammatory Agents; Nitric Oxide/10102-43-9; Glucosamine/3416-24-8; Dinoprostone/363-24-6; Freund's Adjuvant/9007-81-2
CR: | 10102-43-9; 3416-24-8; 363-24-6; 9007-81-2
AB: | OBJECTIVE: Glucosamine, a naturally occurring amino monosaccharide has been used to treat or prevent osteoarthritis in humans. In this study, we evaluated the effect of glucosamine on rat adjuvant arthritis, a model of rheumatoid arthritis. MATERIALS AND METHODS: Adjuvant arthritis was induced in male Wistar rats by injection of Freund's complete adjuvant (FCA) into the right hind paw, and 300 mg/kg of glucosamine, an extra-dose compared with a regular dose for osteoarthritis patients (1.5 g/day, approximately 25 mg/kg), was orally administered once a day to the arthritic rats for 22 days. RESULTS: Glucosamine significantly suppressed the increase in arthritis score (p < 0.05) after day 10 of adjuvant injection, and inhibited the swelling of FCA-injected right and -uninjected left hind paws (p < 0.01) after day 18. In addition, histopathological examination of the arthritic joints revealed that glucosamine suppressed synovial hyperplasia, cartilage destruction and inflammatory cell infiltration. Furthermore, glucosamine reduced the production of nitric oxide and prostaglandin E(2) in plasma (p < 0.05). CONCLUSIONS: These observations suggest that glucosamine is able to suppress the progression of adjuvant arthritis in rats. Glucosamine may be expected as a novel anti-inflammatory agent for treatment of rheumatoid arthritis.

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