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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME16514823
PMID: | 16514823
LR: | 20061115
CED: | 20060306
DCO: | 20060323
Autoren: | Svetlova MS; Ignat'ev VK
Titel: | Experience with glucosamine hydrochloride in the treatment of patients with osteoarthrosis
Quelle: | Terapevticheskii arkhiv; VOL: 77 (12); p. 64-7 /2005/
PM: | Print
SU: | IM
Sprache: | Russian
CY: | Russia (Federation)
JID: | 2984818R
ISSN: | 0040-3660
CO: | TEARAI
DT: | Comparative Study; English Abstract; Journal Article
Schlagwörter
CT: | FEMALE; FOLLOW-UP STUDIES; GLUCOSAMINE/*therapeutic use; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS/*drug therapy; OSTEOARTHRITIS/physiopathology; PAIN MEASUREMENT; RANGE OF MOTION, ARTICULAR/drug effects; TREATMENT OUTCOME
CTG: | WEIBLICH; VERLAUFSSTUDIEN; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE/*Arzneimitteltherapie; OSTEOARTHROSE/Pathophysiologie; SCHMERZMESSUNG; BEREICH DER GELENKBEWEGLICHKEIT/Arzneimittelwirkungen; BEHANDLUNGSERGEBNIS
TE: | Glucosamine/3416-24-8
CR: | 3416-24-8
AB: | AIM: To study efficacy and tolerance of glucosamine hydrochloride (GH) in osteoarthrosis (OA). MATERIAL AND METHODS: GH was given to patients of the study group (n = 30) for 2 months in a dose 1200 mg/day, while diclofenak was administered to the patients from the control group (n = 24) in a dose 100 mg/day. Clinical, laboratory activity of the disease was estimated before the study, after it, 3 and 6 months later. Side effects were also studied. The efficacy of GH therapy was estimated according to the Lequesne's index, pain intensity on vision-analogy scale (VAS), doses of non-steroidal anti-inflammatory drugs during the day. RESULTS: A decrease in the Lequesne's index and pain by VAS while walking, requirements of NSAIDs in OA patients were revealed. No unfavorable aftereffects of GH were observed. CONCLUSION: GH relieves pain, improves function of the affected joints, reduces necessity in NSAIDs. The effect persists for 3 months. No side effects were registered.

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