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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME12498526
PMID: | 12498526
LR: | 20051116
CED: | 20021224
DCO: | 20030327
Autoren: | Goldberg SH; Von Feldt JM; Lonner JH
Titel: | Pharmacologic therapy for osteoarthritis.
Quelle: | American journal of orthopedics (Belle Mead, N.J.); VOL: 31 (12); p. 673-80 /200212/
PM: | Print
SU: | IM
Sprache: | English
CY: | United States
JID: | 9502918
ISSN: | 1078-4519
CO: | AJORFL
Institution: | Department of Orthopaedic Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.
DT: | Journal Article; Review
RN: | 59
Schlagwörter
CT: | ACETAMINOPHEN/therapeutic use; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/therapeutic use; CYCLOOXYGENASE INHIBITORS/therapeutic use; DIETARY SUPPLEMENTS; DRUG THERAPY, COMBINATION; FEMALE; GLUCOSAMINE/therapeutic use; HUMANS; MALE; NARCOTICS/therapeutic use; OSTEOARTHRITIS/diagnosis; OSTEOARTHRITIS/*drug therapy; PAIN MEASUREMENT/drug effects; PHARMACEUTICAL PREPARATIONS/*administration & dosage; PROGNOSIS; RANDOMIZED CONTROLLED TRIALS; RANGE OF MOTION, ARTICULAR/*drug effects; RANGE OF MOTION, ARTICULAR/physiology; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME
CTG: | ACETAMINOPHEN/therapeutische Anwendung; ANTIPHLOGISTIKA, NICHTSTEROIDALE/therapeutische Anwendung; CYCLOOXYGENASEINHIBITOREN/therapeutische Anwendung; NAHRUNGSERGÄNZUNGSMITTEL; ARZNEIMITTEL-KOMBINATIONSTHERAPIE; WEIBLICH; GLUCOSAMIN/therapeutische Anwendung; MENSCH; MÄNNLICH; NARKOTIKA/therapeutische Anwendung; OSTEOARTHROSE/Diagnose; OSTEOARTHROSE/*Arzneimitteltherapie; SCHMERZMESSUNG/Arzneimittelwirkungen; ARZNEIMITTELZUBEREITUNGEN/*Verabreichung & Dosierung; PROGNOSE; RANDOMISIERTE KONTROLLIERTE STUDIEN; BEREICH DER GELENKBEWEGLICHKEIT/*Arzneimittelwirkungen; BEREICH DER GELENKBEWEGLICHKEIT/Physiologie; SCHWEREGRADINDEX EINER KRANKHEIT; BEHANDLUNGSERGEBNIS
TE: | Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Narcotics; Pharmaceutical Preparations; Acetaminophen/103-90-2; Glucosamine/3416-24-8
CR: | 103-90-2; 3416-24-8
AB: | Osteoarthritis is treated with a variety of pharmacologic therapies, including acetaminophen, traditional nonsteroidal anti-inflammatory drugs, cyclo-oxygenase-2 inhibitors, intra-articular steroids, viscosupplements, glucosamine, chondroitin sulfate, capsaicin, and vitamins. In this review, we describe the clinical efficacy and side effects of these pharmaceuticals. Except for vitamins, each of these therapies is effective over the short-term when compared with placebo in controlled clinical trials. Risk-benefit analysis should be considered when prescribing these medications, as side effects are relatively common, and long-term efficacy is variable. In this review, we also examine current and future research on new medications--particularly matrix metalloproteinases and inducible nitric oxide synthase inhibitors--that may modify osteoarthritis.

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