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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME10838710
PMID: | 10838710
LR: | 20061115
CED: | 20000801
DCO: | 20000801
Autoren: | Menzel EJ
Titel: | Polymeres Chondroitinsulfat versus monomeres Glukosamin zur Behandlung der Arthrose. Polymeric chondroitin sulfate vs. monomeric glucosamine for the treatment of osteoarthritis
Quelle: | Wiener medizinische Wochenschrift (1946); VOL: 150 (5); p. 87-90 /2000/
PM: | Print
SU: | IM
Sprache: | German
CY: | AUSTRIA
JID: | 8708475
ISSN: | 0043-5341
CO: | WMWOA4
Institution: | Institut für Immunologie, Universität Wien. ernst.johannes.menzel@univic.ac.at
DT: | English Abstract; Journal Article; Review
RN: | 12
Schlagwörter
CT: | AGGRECANS; CHONDROITIN SULFATES/*metabolism; CHONDROITIN SULFATES/*therapeutic use; EXTRACELLULAR MATRIX PROTEINS/*; GLUCOSAMINE/*metabolism; GLUCOSAMINE/*therapeutic use; HUMANS; LECTINS, C-TYPE; MENISCI, TIBIAL/metabolism; MENISCI, TIBIAL/radionuclide imaging; OSTEOARTHRITIS/*drug therapy; OSTEOARTHRITIS/*metabolism; OSTEOARTHRITIS/radionuclide imaging; PROTEOCHONDROITIN SULFATES/metabolism; PROTEOGLYCANS/metabolism; RADIOPHARMACEUTICALS/diagnostic use; SODIUM PERTECHNETATE TC 99M/diagnostic use; SYNOVIAL FLUID/metabolism; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON
CTG: | AGGREKANE; CHONDROITINSULFATE/*Stoffwechsel; CHONDROITINSULFATE/*therapeutische Anwendung; EXTRAZELLULÄRE MATRIXPROTEINE/*; GLUCOSAMIN/*Stoffwechsel; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; LECTINE, C-TYP-; MENISKEN, KNIEGELENK-/Stoffwechsel; MENISKEN, KNIEGELENK-/Szintigraphie; OSTEOARTHROSE/*Arzneimitteltherapie; OSTEOARTHROSE/*Stoffwechsel; OSTEOARTHROSE/Szintigraphie; PROTEOCHONDROITIN-SULFATE/Stoffwechsel; PROTEOGLYCANE/Stoffwechsel; RADIOPHARMAKA/diagnostische Verwendung; NATRIUMPERTECHNETAT TC 99M/diagnostische Verwendung; SYNOVIALFLÜSSIGKEIT/Stoffwechsel; EINZELPHOTONEN-EMISSIONSCOMPUTERTOMOGRAPHIE
TE: | Aggrecans; Extracellular Matrix Proteins; Lectins, C-Type; Proteochondroitin Sulfates; Proteoglycans; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m/23288-60-0; Glucosamine/3416-24-8; Chondroitin Sulfates/9007-28-7
CR: | 23288-60-0; 3416-24-8; 9007-28-7
AB: | Two potentially chondro-protective substances are compared with each other: polymeric chondroitin sulfate and monomeric glucosamine. Chondroitin-sulfate is characterized by tropism for cartilage, i.e. it is preferentially incorporated into cartilagenous tissue. This quality could be of interest in the SPECT-analysis of osteoarthritic knee joints. In contrast to the classic agents Ibuprofen and Indomethacin, the antiinflammatory action of chondroitin-sulfate is less prominent, but the drug does not show any toxic side effects. Glucosamine on the other hand is a multifunctional precursor of the glycosaminoglycan synthesis in general. It lacks the cartilage tropism of chondroitin-sulfate. Into what sort of a glycosaminoglycan glucosamine is eventually integrated, depends therefore on the nature of the cells participating in the biosynthesis.

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