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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME10966840
PMID: | 10966840
LR: | 20061115
CED: | 20001013
DCO: | 20001013
Autoren: | Das A Jr; Hammad TA
Titel: | Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis.
Quelle: | Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society; VOL: 8 (5); p. 343-50 /200009/
PM: | Print
SU: | IM
Sprache: | English
CY: | ENGLAND
JID: | 9305697
ISSN: | 1063-4584
Institution: | Hendersonville Orthopedics Associates, Hendersonville, North Carolina 28739, USA.
DT: | Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | AGED; ANTIRHEUMATIC AGENTS/*therapeutic use; CHONDROITIN SULFATES/*therapeutic use; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; GLUCOSAMINE/*therapeutic use; HUMANS; MALE; MANGANESE COMPOUNDS/therapeutic use; MIDDLE AGED; OSTEOARTHRITIS, KNEE/*drug therapy; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME
CTG: | ALTE MENSCHEN; ANTIRHEUMATIKA/*therapeutische Anwendung; CHONDROITINSULFATE/*therapeutische Anwendung; DOPPELBLINDMETHODE; ARZNEIMITTEL-KOMBINATIONSTHERAPIE; WEIBLICH; VERLAUFSSTUDIEN; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; MÄNNLICH; MANGANVERBINDUNGEN/therapeutische Anwendung; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; SCHWEREGRADINDEX EINER KRANKHEIT; BEHANDLUNGSERGEBNIS
TE: | Antirheumatic Agents; Manganese Compounds; Glucosamine/3416-24-8; Chondroitin Sulfates/9007-28-7
CR: | 3416-24-8; 9007-28-7
AB: | OBJECTIVES: The objective of this study was to evaluate the oral combination of glucosamine HCl, sodium chondroitin sulfate and manganese ascorbate for the treatment of osteoarthritis (OA) of the knee. DESIGN: A randomized placebo-controlled study design was implemented. We recruited 93 patients with OA of the knee from a single center. The intervention group received 1000 mg FCHG49 glucosamine HCl, 800 mg TRH122 low molecular weight sodium chondroitin sulfate and 152 mg manganese ascorbate twice daily (Cosamin DS). Patients were evaluated initially and then every 2 months for 6 months. The primary outcome was the Lesquene Index of severity of osteoarthritis of the knee (ISK). RESULTS: Patients with radiographically mild or moderate OA (N=72) in the intervention group showed significant improvement in the ISK at 4 and 6 months (P=0.003 and P=0.04, respectively). The response rate to the medication was 52% vs a 28% response rate to placebo. Patients with radiographically severe osteoarthritis (N=21) did not show significant improvements in the ISK. There was a 17% incidence of adverse events in the intervention group and 19% in the placebo group. CONCLUSIONS: The studied combination of glucosamine HCl, sodium chondroitin sulfate and manganese ascorbate was found to be effective for the treatment of radiographically mild to moderate OA of the knee as measured by the ISK. This is the first U.S. study of these agents. - CNOTE: Copyright 2000 OsteoArthritis Research Society International.

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