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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/374 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME01689600
PMID: | 1689600
LR: | 20061115
CED: | 19900402
DCO: | 19900402
Autoren: | Sharif M; Rook G; Wilkinson LS; Worrall JG; Edwards JC
Titel: | Terminal N-acetylglucosamine in chronic synovitis.
Quelle: | British journal of rheumatology; VOL: 29 (1); p. 25-31 /199002/
PM: | Print
SU: | AIM IM
Sprache: | English
CY: | ENGLAND
JID: | 8302415
ISSN: | 0263-7103
CO: | BJRHDF
Institution: | Department of Microbiology, University College and Middlesex Hospital, School of Medicine.
DT: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ACETYLGLUCOSAMINE/*metabolism; ARTHRITIS, RHEUMATOID/metabolism; CELL MEMBRANE/metabolism; CHEMISTRY; CHRONIC DISEASE; CYTOPLASMIC GRANULES/metabolism; EXTRACELLULAR SPACE/metabolism; GLUCOSAMINE/*analogs & derivatives; HUMANS; OSTEOARTHRITIS/metabolism; REFERENCE VALUES; RHEUMATOID NODULE/metabolism; STAINING AND LABELING; SYNOVITIS/*metabolism
CTG: | ACETYLGLUCOSAMIN/*Stoffwechsel; ARTHRITIS, RHEUMATOIDE/Stoffwechsel; ZELLMEMBRAN/Stoffwechsel; CHEMIE; CHRONISCHE KRANKHEIT; ZYTOPLASMATISCHE GRANULA/Stoffwechsel; EXTRAZELLULÄRRAUM/Stoffwechsel; GLUCOSAMIN/*Analoge & Derivate; MENSCH; OSTEOARTHROSE/Stoffwechsel; REFERENZWERTE; RHEUMATOIDER KNOTEN/Stoffwechsel; FÄRBEN UND ETIKETTIEREN; SYNOVITIS/*Stoffwechsel
TE: | Glucosamine/3416-24-8; Acetylglucosamine/7512-17-6
CR: | 3416-24-8; 7512-17-6
AB: | The distribution of terminal GlcNAc residues in normal and diseased synovial tissue has been studied using a mouse monoclonal antibody (mAb) which binds to terminal N-acetylglucosamine (GlcNAc). Normal human connective tissue, including synovium, showed no staining for terminal GlcNAc. Normal epithelial tissues, including tonsillar epithelium, skin, small intestinal epithelium and salivary epithelium showed cellular staining. Synovium from patients with definite rheumatoid arthritis showed dense granular staining of macrophages. In addition, synovium from 9 of 12 patients with definite rheumatoid arthritis showed reticular extracellular staining indicating deposition of material bearing terminal GlcNAc in the connective tissue stroma. The extracellular staining was not seen in synovium from patients with osteoarthritis. Extracellular material bearing terminal GlcNAc may act as an inflammatory stimulus in rheumatoid arthritis, either by acting as antigen or by interaction with receptors on macrophage membranes which also recognize GlcNAc on bacterial material, thus triggering biochemical pathways normally occurring in response to the presence of micro-organisms.

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