Dokumente
Suchschritt : FT=glucosamine AND FT=osteoarthritis
» Fenster schließen »

2/397 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME00699625
PMID: | 699625
LR: | 20041117
CED: | 19781220
DCO: | 19781220
Autoren: | Dieppe PA
Titel: | Nephrotoxicity studies on aspirin and diflunisal.
Quelle: | Current medical research and opinion; VOL: 5 (7); p. 515-9 /1978/
PM: | Print
SU: | IM
Sprache: | English
CY: | ENGLAND
JID: | 0351014
ISSN: | 0300-7995
CO: | CMROCX
DT: | Journal Article
Schlagwörter
CT: | ACETYLGLUCOSAMINE/urine; ANALGESICS/*adverse effects; ANALGESICS/therapeutic use; ASPIRIN/*adverse effects; ASPIRIN/therapeutic use; BIPHENYL COMPOUNDS/*adverse effects; BIPHENYL COMPOUNDS/therapeutic use; EPITHELIAL CELLS; FEMALE; HUMANS; KIDNEY DISEASES/*chemically induced; MALE; OSTEOARTHRITIS/drug therapy
CTG: | ACETYLGLUCOSAMIN/Harn; ANALGETIKA/*unerwünschte Nebenwirkungen; ANALGETIKA/therapeutische Anwendung; ASPIRIN/*unerwünschte Nebenwirkungen; ASPIRIN/therapeutische Anwendung; BIPHENYLVERBINDUNGEN/*unerwünschte Nebenwirkungen; BIPHENYLVERBINDUNGEN/therapeutische Anwendung; EPITHELZELLEN; WEIBLICH; MENSCH; NIERENKRANKHEITEN/*chemisch hervorgerufen; MÄNNLICH; OSTEOARTHROSE/Arzneimitteltherapie
TE: | Analgesics; Biphenyl Compounds; Aspirin/50-78-2; Acetylglucosamine/7512-17-6
CR: | 50-78-2; 7512-17-6
AB: | Some of the difficulties encountered in investigations of long-term drug nephrotoxicity are reviewed, and the evidence for acute and chronic renal damage induced by aspirin is discussed. Two studies were carried out to investigate the acute effects of diflunisal on the kidney, and to compare its effects with those of aspirin. Measurements were made before, during and after drug intake, of epithelial cells and lysosomal enzyme (beta-d-n-acetyl glucosaminidase) excretion in urine. Diflunisal caused no change in cell excretion and no increase in enzyme secretion in 6 normal volunteers. In a comparative study against aspirin, two groups of 12 patients being treated for osteoarthrosis were observed over an 8-week period. Enzyme excretion increased in both groups and appeared to be dose related. The increase, however, was relatively greater in the aspirin group. The possible significance of these findings is discussed.

» Volltext »
» Fenster schließen »