| ND: |
ME12596539 |
| PMID: |
12596539 |
| LR: |
20061115 |
| CED: |
20030224 |
| DCO: |
20030324 |
| Autoren: |
Zupanets IA; Bezdetko NV; Dedukh NV; Otrishko IA |
| Titel: |
Eksperimental'noe izuchenie vliianiia gliukozamina gidrokhlorida na metabolicheskie i reparativnye protsessy v soedinitel'notkannykh strukturakh. Experimental study of the effect of glucosamine hydrochloride on metabolic and repair processes in connective tissue structures |
| Quelle: |
Eksperimental'naia i klinicheskaia farmakologiia; VOL: 65 (6); p. 67-9 /2002 Nov-Dec/ |
| PM: |
Print |
| SU: |
IM |
| Sprache: |
Russian |
| CY: |
Russia |
| JID: |
9215981 |
| ISSN: |
0869-2092 |
| CO: |
EKFAE9 |
| Institution: |
Clinical Pharmacy Department, National Pharmaceutical Academy of Ukraine, ul. Pushkinskaya 53, Kharkov 61002, Ukraine. |
| DT: |
English Abstract; Journal Article |
| Schlagwörter |
| CT: |
ANIMALS; CONNECTIVE TISSUE/*injuries; CONNECTIVE TISSUE/*metabolism; CORNEA/metabolism; GLUCOSAMINE/*pharmacology; GLYCOSAMINOGLYCANS/metabolism; KERATITIS/etiology; KERATITIS/metabolism; OSTEOARTHRITIS, HIP/etiology; OSTEOARTHRITIS, HIP/metabolism; RABBITS; RATS; WOUND HEALING/*drug effects |
| CTG: |
TIER; BINDEGEWEBE/*Verletzungen; BINDEGEWEBE/*Stoffwechsel; KORNEA/Stoffwechsel; GLUCOSAMIN/*Pharmakologie; GLYCOSAMINO-GLYCANE/Stoffwechsel; KERATITIS/Ätiologie; KERATITIS/Stoffwechsel; OSTEOARTHROSE, HÜFT-/Ätiologie; OSTEOARTHROSE, HÜFT-/Stoffwechsel; KANINCHEN; RATTUS; WUNDHEILUNG/*Arzneimittelwirkungen |
| TE: |
Glycosaminoglycans; Glucosamine/3416-24-8 |
| CR: |
3416-24-8 |
| AB: |
The effects of glucosamine hydrochloride on the metabolic and repair processes were studied on a model of post-traumatic osteoarthrosis in the articular cartilage and on a model of post-traumatic keratitis in the cornea. The administration of glucosamine hydrochloride stimulated repair and favored inhibition of dystrophic post-traumatic processes in the connective-tissue structures. It is suggested that a probable mechanism of the drug action consists in stimulation of the synthesis of glucosaminoglycanes and collagen. |