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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/378 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME03345232
PMID: | 3345232
LR: | 20041117
CED: | 19880329
DCO: | 19880329
Autoren: | Sato H; Takahashi T; Ide H; Fukushima T; Tabata M; Sekine F; Kobayashi K; Negishi M; Niwa Y
Titel: | Antioxidant activity of synovial fluid, hyaluronic acid, and two subcomponents of hyaluronic acid. Synovial fluid scavenging effect is enhanced in rheumatoid arthritis patients.
Quelle: | Arthritis and rheumatism; VOL: 31 (1); p. 63-71 /198801/
PM: | Print
SU: | AIM IM
Sprache: | English
CY: | UNITED STATES
JID: | 0370605
ISSN: | 0004-3591
CO: | ARHEAW
Institution: | First Department of Internal Medicine, School of Medicine, Showa University, Tokyo, Japan.
DT: | Journal Article
Schlagwörter
CT: | ACETYLGLUCOSAMINE/*pharmacology; ADULT; AGED; ANTIOXIDANTS/*pharmacology; ARTHRITIS, RHEUMATOID/*metabolism; FEMALE; FREE RADICALS; GLUCOSAMINE/*analogs & derivatives; GLUCURONATES/*pharmacology; GLUCURONIC ACID; HUMANS; HYALURONIC ACID/*pharmacology; MALE; MIDDLE AGED; OSTEOARTHRITIS/metabolism; OXYGEN/*antagonists & inhibitors; OXYGEN/metabolism; OXYGEN CONSUMPTION/drug effects; SYNOVIAL FLUID/*physiology
CTG: | ACETYLGLUCOSAMIN/*Pharmakologie; ERWACHSENER; ALTE MENSCHEN; ANTIOXYDANZIEN/*Pharmakologie; ARTHRITIS, RHEUMATOIDE/*Stoffwechsel; WEIBLICH; FREIE RADIKALE; GLUCOSAMIN/*Analoge & Derivate; GLUCURONATE/*Pharmakologie; GLUCURONSÄURE; MENSCH; HYALURONSÄURE/*Pharmakologie; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE/Stoffwechsel; SAUERSTOFF/*Antagonisten & Inhibitoren; SAUERSTOFF/Stoffwechsel; SAUERSTOFFVERBRAUCH/Arzneimittelwirkungen; SYNOVIALFLÜSSIGKEIT/*Physiologie
TE: | Antioxidants; Free Radicals; Glucuronates; Glucosamine/3416-24-8; Glucuronic Acid/576-37-4; Acetylglucosamine/7512-17-6; Oxygen/7782-44-7; Hyaluronic Acid/9004-61-9
CR: | 3416-24-8; 576-37-4; 7512-17-6; 7782-44-7; 9004-61-9
AB: | To test the scavenging of reactive oxygen species (ROS), we added synovial fluids from patients with rheumatoid arthritis (RA) and osteoarthritis, as well as hyaluronic acid (HA) and its 2 subcomponents, D-glucuronic acid and N-acetyl-D-glucosamine, to 2 ROS-generating systems, activated neutrophils and xanthine-xanthine oxidase. Synovial fluid from RA patients, HA, and D-glucuronic acid markedly decreased the O2-, H2O2, OH., and chemiluminescence measured in both systems. HA and synovial fluid, which are known to be susceptible to degradation by excessive ROS in RA patients, also seem to play an active role in protecting articular tissues from oxidative damage.

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