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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME12505481
PMID: | 12505481
LR: | 20041117
CED: | 20021230
DCO: | 20030421
Autoren: | Bruyere O; Honore A; Ethgen O; Rovati LC; Giacovelli G; Henrotin YE; Seidel L; Reginster JY
Titel: | Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate.
Quelle: | Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society; VOL: 11 (1); p. 1-5 /200301/
PM: | Print
SU: | IM
Sprache: | English
CY: | England
JID: | 9305697
ISSN: | 1063-4584
Institution: | WHO Collaborating Center for Public Health Aspect of Osteoarticular Disorders, Liege, Belgium.
DT: | Clinical Trial; Journal Article; Randomized Controlled Trial
Schlagwörter
CT: | AGED; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; GLUCOSAMINE/*therapeutic use; HUMANS; MALE; OSTEOARTHRITIS, KNEE/*drug therapy; OSTEOARTHRITIS, KNEE/radiography; PROGNOSIS; PROSPECTIVE STUDIES
CTG: | ALTE MENSCHEN; KRANKHEITSPROGRESSION; DOPPELBLINDMETHODE; WEIBLICH; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; MÄNNLICH; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; OSTEOARTHROSE, KNIE/Röntgenuntersuchung; PROGNOSE; PROSPEKTIVE STUDIEN
TE: | Glucosamine/3416-24-8
CR: | 3416-24-8
AB: | OBJECTIVE: To investigate the relationship between baseline radiographic severity of knee osteoarthritis (OA) and the importance of long-term joint space narrowing. DESIGN: Sub-analysis from a three-year randomized, placebo-controlled, prospective study, of 212 patients with knee OA, recruited in an osteoarthritic outpatient clinic and having been part of a study evaluating the effect of glucosamine sulfate on symptom and structure modification in knee OA. MATERIAL AND METHODS: Measurements of mean joint space width (JSW), assessed by a computer-assisted method, were performed at baseline and after 3 years, on weightbearing anteroposterior knee radiographs. RESULTS: In the placebo group, baseline JSW was significantly and negatively correlated with the joint space narrowing observed after 3 years (r=-0.34, P=0.003). In the lowest quartile of baseline mean JSW (<4.5mm), the JSW increased after 3 years by (mean (S.D.)) 3.8% (23.8) in the placebo group and 6.2% (17.5) in the glucosamine sulfate group. The difference between the two groups in these patients with the most severe OA at baseline was not statistically significant (P=0.70). In the highest quartile of baseline mean JSW (>6.2mm), a joint space narrowing of 14.9% (17.9) occurred in the placebo group after 3 years while patients from the glucosamine sulfate group only experienced a narrowing of 6.0% (15.1). Patients with the most severe OA at baseline had a RR of 0.42 (0.17-1.01) to experience a 0.5mm joint space narrowing over 3 years, compared to those with the less affected joint. In patients with mild OA, i.e. in the highest quartile of baseline mean JSW, glucosamine sulfate use was associated with a trend (P=0.10) towards a significant reduction in joint space narrowing. CONCLUSION: These results suggest that patients with the less severe radiographic knee OA will experience, over 3 years, the most dramatic disease progression in terms of joint space narrowing. Such patients may be particularly responsive to structure-modifying drugs. - CNOTE: Copyright 2003 OsteoArthritis Research Society International. Published by Elsevier Science Ltd.

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