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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME07889262
PMID: | 7889262
LR: | 20061115
CED: | 19950419
DCO: | 19950419
Autoren: | Manicourt DH; Druetz-Van Egeren A; Haazen L; Nagant de Deuxchaisnes C
Titel: | Effects of tenoxicam and aspirin on the metabolism of proteoglycans and hyaluronan in normal and osteoarthritic human articular cartilage.
Quelle: | British journal of pharmacology; VOL: 113 (4); p. 1113-20 /199412/
PM: | Print
SU: | IM
Sprache: | English
CY: | ENGLAND
JID: | 7502536
ISSN: | 0007-1188
CO: | BJPCBM
Institution: | Saint-Luc University Hospital, University of Louvain, Brussels, Belgium.
DT: | Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ADULT; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/*pharmacology; ASPIRIN/*pharmacology; CARTILAGE, ARTICULAR/drug effects; CARTILAGE, ARTICULAR/*metabolism; CHONDROITIN/metabolism; HUMANS; HYALURONIC ACID/biosynthesis; HYALURONIC ACID/*metabolism; MIDDLE AGED; OSTEOARTHRITIS/*metabolism; PIROXICAM/*analogs & derivatives; PIROXICAM/pharmacology; PROTEOGLYCANS/biosynthesis; PROTEOGLYCANS/*metabolism
CTG: | ERWACHSENER; ALTE MENSCHEN; ANTIPHLOGISTIKA, NICHTSTEROIDALE/*Pharmakologie; ASPIRIN/*Pharmakologie; KNORPEL, GELENK-/Arzneimittelwirkungen; KNORPEL, GELENK-/*Stoffwechsel; CHONDROITIN/Stoffwechsel; MENSCH; HYALURONSÄURE/Biosynthese; HYALURONSÄURE/*Stoffwechsel; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE/*Stoffwechsel; PIROXICAM/*Analoge & Derivate; PIROXICAM/Pharmakologie; PROTEOGLYCANE/Biosynthese; PROTEOGLYCANE/*Stoffwechsel
TE: | Anti-Inflammatory Agents, Non-Steroidal; Proteoglycans; Piroxicam/36322-90-4; Aspirin/50-78-2; tenoxicam/59804-37-4; Hyaluronic Acid/9004-61-9; Chondroitin/9007-27-6
CR: | 36322-90-4; 50-78-2; 59804-37-4; 9004-61-9; 9007-27-6
AB: | 1. As nonsteroidal anti-inflammatory drugs may impair the ability of the chondrocyte to repair its damaged extracellular matrix, we explored the changes in the metabolism of newly synthesized proteoglycan (PG) and hyaluronan (HA) molecules produced by tenoxicam and aspirin in human normal cartilage explants and in osteoarthritic (OA) cartilage from age-matched donors. 2. Explants were sampled from the medial femoral condyle and were classified by use of Mankin's histological-histochemical grading system. Cartilage specimens were normal in 10 subjects, exhibited moderate OA (MOA) in 10 and had severe OA (SOA) in 10. 3. Cartilage explants were pulsed with [3H]-glucosamine and chased in the absence and in the presence of either aspirin (190 micrograms ml-1) or tenoxicam (4-16 micrograms ml-1). After papain digestion, the labelled chondroitin sulphate ([3H]-PGs) and HA([3H]-HA) molecules present in the tissue and media were purified by anion-exchange chromatography. 4. In normal cartilage as well as in explants with MOA and SOA aspirin reduced more strongly PG and HA synthesis than the loss of [3H]-HA and [3H]-PGs. 5. In normal cartilage, tenoxicam did not affect PG metabolism whereas it reduced HA synthesis in a dose-dependent manner and did not change or even increased the net loss of [3H]-HA. In contrast, in OA cartilage, tenoxicam produced a stronger reduction in the loss of [3H]-PGs than in PG synthesis and this decrease occurred at lower concentrations in cartilage with SOA (4-8 micrograms ml-1) than in cartilage with MOA (8-16 micrograms ml-1).(ABSTRACT TRUNCATED AT 250 WORDS)

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