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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME10693368
PMID: | 10693368
LR: | 20041117
CED: | 20000316
DCO: | 20000316
Autoren: | Rindone JP; Hiller D; Collacott E; Nordhaugen N; Arriola G
Titel: | Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee.
Quelle: | The Western journal of medicine; VOL: 172 (2); p. 91-4 /200002/
PM: | Print
SU: | AIM IM
Sprache: | English
CY: | UNITED STATES
JID: | 0410504
ISSN: | 0093-0415
CO: | WJMDA2
Institution: | Veterans Affairs Medical Center, Prescott, AZ 86313, USA. joseph.rindone@med.va.gov
DT: | Clinical Trial; Journal Article; Randomized Controlled Trial
Schlagwörter
CT: | AGED; DOUBLE-BLIND METHOD; FEMALE; GLUCOSAMINE/*therapeutic use; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE/*drug therapy; TREATMENT OUTCOME
CTG: | ALTE MENSCHEN; DOPPELBLINDMETHODE; WEIBLICH; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; BEHANDLUNGSERGEBNIS
TE: | Glucosamine/3416-24-8
CR: | 3416-24-8
NOTE: | Comment in: West J Med. 2000 Feb;172(2):95; Ref.PMID: 10693369
AB: | OBJECTIVE: To determine the effectiveness of glucosamine in reducing pain from osteoarthritis of the knee. DESIGN: Randomized, double-blind parallel trial of glucosamine 500 mg three times daily or a placebo for 2 months. SETTING: Veterans Affairs Medical Center, Prescott, AZ. PARTICIPANTS: Ninety-eight patients aged 34 to 81 being treated for osteoarthritis of the knee. MAIN OUTCOME MEASURES: Pain intensity both at rest and while walking as assessed by a visual analog scale at baseline and after 30 and 60 days of treatment. RESULTS: Forty-nine patients were randomly allocated to each group. There was no statistical difference between the two groups in scores on the visual analog scale at 30 days for resting (mean [SD] score placebo group 3.5 [2.7] vs 3.3 [2.4] glucosamine group, P = 0.66) or walking (5.1 [2.6] vs 5.3 [2.4], P = 0.69); there was also no difference at 60 days for resting (3.4 [2.5] vs 3.2 [2.5], P = 0.81) or walking (4.9 [2.2] vs 4.9 [2.8], P = 0.90). There was also no statistical difference between groups in the mean change from baseline in scores on the visual analog scale (mean [SD] change for walking at 60 days placebo group -1.5 [2.5] vs glucosamine group -1.4 [3.0], P = 0.77). Two participants taking glucosamine and 4 taking placebo withdrew from the study due to adverse side effects (P = 0.67). CONCLUSION: Glucosamine was no better than placebo in reducing pain from osteoarthritis of the knee in this group of patients.

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