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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME00131804
PMID: | 131804
LR: | 20031114
CED: | 19760802
DCO: | 19760802
Autoren: | McDevitt CA; Muir H
Titel: | Biochemical changes in the cartilage of the knee in experimental and natural osteoarthritis in the dog.
Quelle: | The Journal of bone and joint surgery. British volume; VOL: 58 (1); p. 94-101 /197602/
PM: | Print
SU: | AIM IM
Sprache: | English
CY: | ENGLAND
JID: | 0375355
ISSN: | 0301-620X
CO: | JBSUAK
DT: | Journal Article
Schlagwörter
CT: | ANIMALS; BODY WATER; CARTILAGE, ARTICULAR/*analysis; CARTILAGE, ARTICULAR/metabolism; CARTILAGE, ARTICULAR/pathology; DOGS; FEMALE; FEMUR; GALACTOSAMINE/analysis; GLUCOSAMINE/analysis; GLYCOSAMINOGLYCANS/*analysis; KNEE/*pathology; MALE; OSTEOARTHRITIS/metabolism; OSTEOARTHRITIS/*pathology; PAPAIN/diagnostic use; PATELLA; PROTEOGLYCANS/*analysis; PROTEOGLYCANS/biosynthesis; TIBIA; URONIC ACIDS/analysis
CTG: | TIER; KÖRPERWASSER; KNORPEL, GELENK-/*Analyse; KNORPEL, GELENK-/Stoffwechsel; KNORPEL, GELENK-/Pathologie; HUNDE; WEIBLICH; FEMUR; GALACTOSAMIN/Analyse; GLUCOSAMIN/Analyse; GLYCOSAMINO-GLYCANE/*Analyse; KNIE/*Pathologie; MÄNNLICH; OSTEOARTHROSE/Stoffwechsel; OSTEOARTHROSE/*Pathologie; PAPAIN/diagnostische Verwendung; PATELLA; PROTEOGLYCANE/*Analyse; PROTEOGLYCANE/Biosynthese; TIBIA; URONSÄUREN/Analyse
TE: | Glycosaminoglycans; Proteoglycans; Uronic Acids; Glucosamine/3416-24-8; Galactosamine/7535-00-4; Papain/E.C. 3.4.22.2
CR: | 3416-24-8; 7535-00-4; E.C. 3.4.22.2
AB: | Biochemical changes in the articular cartilage of the knees of mature dogs, one with natural and four with surgically induced osteoarthritis, have been investigated. The four dogs were killed three, six, nine and forty-eight weeks after division of the right anterior cruciate ligament, the left knees serving as controls. The cartilage of the joints operated on was thicker and more hydrated than the control cartilage; the proteoglycans were more easily extracted and had higher galactosamine/glucosamine molar ratios. The proportion of proteoglycans firmly associated with collagen, and hence not extractable, diminished before fibrillation was demonstrable by indian ink staining of the surface. These biochemical changes were present throughout the entire cartilage of the joints operated on of the dogs killed more than three weeks later, and of the dog with natural osteoarthritis. The results suggest that in response to altered mechanical stresses the chondrocytes synthesise proteoglycans that contain more chondroitin sulphate relative to keratin sulphate than normally, as in immature articular cartilage.

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