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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME11178943
PMID: | 11178943
LR: | 20061115
CED: | 20010222
DCO: | 20010419
Autoren: | Johnson KA; Hulse DA; Hart RC; Kochevar D; Chu Q
Titel: | Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritis.
Quelle: | Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society; VOL: 9 (1); p. 14-21 /200101/
PM: | Print
SU: | IM
Sprache: | English
CY: | England
JID: | 9305697
ISSN: | 1063-4584
Institution: | Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio 43210-1089, USA. johnson.2064@osu.edu
DT: | Journal Article; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ADMINISTRATION, ORAL; ANIMALS; CARTILAGE, ARTICULAR/*drug effects; CHONDROITIN SULFATES/administration & dosage; CHONDROITIN SULFATES/*pharmacology; CROSS-SECTIONAL STUDIES; DOGS; FEMALE; GLUCOSAMINE/administration & dosage; GLUCOSAMINE/*pharmacology; GLYCOSAMINOGLYCANS/*metabolism; KNEE JOINT/physiopathology; LIGAMENTS, ARTICULAR/physiopathology; LONGITUDINAL STUDIES; MALE; MANGANESE COMPOUNDS/administration & dosage; MANGANESE COMPOUNDS/*pharmacology; SYNOVIAL FLUID/*chemistry
CTG: | APPLIKATION, ORALE; TIER; KNORPEL, GELENK-/*Arzneimittelwirkungen; CHONDROITINSULFATE/Verabreichung & Dosierung; CHONDROITINSULFATE/*Pharmakologie; QUERSCHNITTSSTUDIEN; HUNDE; WEIBLICH; GLUCOSAMIN/Verabreichung & Dosierung; GLUCOSAMIN/*Pharmakologie; GLYCOSAMINO-GLYCANE/*Stoffwechsel; KNIEGELENK/Pathophysiologie; BÄNDER, GELENK-/Pathophysiologie; LONGITUDINALSTUDIEN; MÄNNLICH; MANGANVERBINDUNGEN/Verabreichung & Dosierung; MANGANVERBINDUNGEN/*Pharmakologie; SYNOVIALFLÜSSIGKEIT/*Chemie
TE: | Glycosaminoglycans; Manganese Compounds; Glucosamine/3416-24-8; A73025/64082-61-7; Chondroitin Sulfates/9007-28-7
CR: | 3416-24-8; 64082-61-7; 9007-28-7
AB: | OBJECTIVE: To evaluate effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate (CS-G-M) on articular cartilage metabolism in dogs with cranial cruciate ligament (CCL) deficient and reconstructed knees, as reflected by concentrations of synovial fluid 3B3, 7D4 and total sulfated glycosaminoglycan (GAG). METHODS: Sixteen adult dogs that underwent unilateral CCL transection were randomized into four groups. Thereafter, group I (N=3) had a sham CCL reconstruction, group II (N=3) had CS-G-M and sham CCL reconstruction, group III (N=5) had CCL reconstruction, and group IV (N=5) had CS-G-M and CCL reconstruction. Synovial fluid collected at 0, 1, 3 and 5 months was examined by ELISA for 3B3 and 7D4 epitope, and by DMMB assay for total GAG. RESULTS: Synovial fluid from CCL transected knees of CS-G-M treated dogs contained significantly elevated concentrations of 3B3 (P=0.029), 7D4 (P=0.036) and 7D4/GAG (P=0.007) in comparison to controls, in a cross-sectional analysis at 3 months. Furthermore, 7D4 and 7D4/GAG concentrations remained significantly elevated (P=0.012) in CCL transected knees of CS-G-M treated dogs over the 5 month period. However, when epitope concentrations were expressed as a ratio of CCL-transected to contralateral non-operated knee, treatment effect of CS-G-M was no longer significant. Reconstruction of the CCL had no significant effect on synovial fluid epitope. CONCLUSIONS: Administration of CS-G-M was associated with altered concentrations of 3B3 and 7D4 epitope in synovial fluid, suggesting that these compounds may act to modulate articular cartilage matrix metabolism in vivo.

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