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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME11795556
PMID: | 11795556
LR: | 20051117
CED: | 20020117
DCO: | 20020201
Autoren: | McColl GJ
Titel: | Pharmacological therapies for the treatment of osteoarthritis.
Quelle: | The Medical journal of Australia; VOL: 175 Suppl; p. S108-11 /20011119/
PM: | Print
SU: | IM
Sprache: | English
CY: | Australia
JID: | 0400714
ISSN: | 0025-729X
CO: | MJAUAJ
Institution: | Centre for Rheumatic Diseases, Royal Melbourne Hospital, Parkville, VIC. g.mccoll@medicine.unimelb.edu.au
DT: | Journal Article; Review
RN: | 30
Schlagwörter
CT: | ACETAMINOPHEN/therapeutic use; ANALGESICS, NON-NARCOTIC/therapeutic use; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/therapeutic use; ARTHRITIS/*drug therapy; CYCLOOXYGENASE INHIBITORS/therapeutic use; HUMANS; LACTONES/therapeutic use; PYRAZOLES; SULFONAMIDES/therapeutic use; SULFONES
CTG: | ACETAMINOPHEN/therapeutische Anwendung; ANALGETIKA, NICHTNARKOTISCHE/therapeutische Anwendung; ANTIPHLOGISTIKA, NICHTSTEROIDALE/therapeutische Anwendung; ARTHRITIS/*Arzneimitteltherapie; CYCLOOXYGENASEINHIBITOREN/therapeutische Anwendung; MENSCH; LACTONE/therapeutische Anwendung; PYRAZOLE; SULFONAMIDE/therapeutische Anwendung; SULFONE
TE: | Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Lactones; Pyrazoles; Sulfonamides; Sulfones; rofecoxib; Acetaminophen/103-90-2; celecoxib/169590-42-5
CR: | 103-90-2; 169590-42-5
AB: | Non-pharmacological interventions are the first-line therapy for osteoarthritis. If non-pharmacological therapy fails, paracetamol (up to 4 g daily) should be added. If paracetamol fails, the patient's risk factors for gastrointestinal and renal disease should be assessed. In patients with gastrointestinal risk factors, a COX-2-specific inhibitor (CSI) would be used in preference to a conventional non-steroidal anti-inflammatory drug (NSAID). In patients with renal risk factors, NSAIDs and CSIs should be used with care. In patients who continue to have problems, other treatments should be considered; these might include intra-articular hyaluronan or depot corticosteroid, analgesia or glucosamine.

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