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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/149 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME15095620
PMID: | 15095620
LR: | 20061115
CED: | 20040420
DCO: | 20040520
Autoren: | Reginster JY
Titel: | Chondromodulation en 2003: rêve ou réalité? Chondromodulation in 2003: dream or reality?
Quelle: | Revue médicale de la Suisse romande; VOL: 124 (2); p. 85-7 /200402/
PM: | Print
SU: | IM
Sprache: | French
CY: | Switzerland
JID: | 0421524
ISSN: | 0035-3655
CO: | RMSRA6
Institution: | Service de santé publique, d'épidémiologie et économie de la santé, CHU Sart Tilman-Bâtiment B23 B-4000 Liège. jyreginster@ulg.ac.be
DT: | English Abstract; Journal Article; Review
RN: | 26
Schlagwörter
CT: | ANTHRAQUINONES/therapeutic use; CHONDROCYTES/*physiology; CHONDROITIN SULFATES/physiology; CHONDROITIN SULFATES/therapeutic use; GLUCOSAMINE/physiology; GLUCOSAMINE/therapeutic use; HUMANS; OSTEOARTHRITIS/*drug therapy; PLANT EXTRACTS/therapeutic use
CTG: | ANTHRACHINONE/therapeutische Anwendung; CHONDROZYTEN/*Physiologie; CHONDROITINSULFATE/Physiologie; CHONDROITINSULFATE/therapeutische Anwendung; GLUCOSAMIN/Physiologie; GLUCOSAMIN/therapeutische Anwendung; MENSCH; OSTEOARTHROSE/*Arzneimitteltherapie; PFLANZENEXTRAKTE/therapeutische Anwendung
TE: | Anthraquinones; Plant Extracts; diacetylrhein/13739-02-1; Glucosamine/3416-24-8; Chondroitin Sulfates/9007-28-7
CR: | 13739-02-1; 3416-24-8; 9007-28-7
AB: | The use of drugs for the treatment of osteoarthritis, with a view to obtain a long-term symptomatic as well as structural benefit, is still in a preliminary state. Nowadays, matricial precursors, such as glucosamine sulfate, are an interesting approach in this indication. They have demonstrated a symptomatic efficacy comparable to that of N.S.A.I.D., with significantly reduced side-effects. Glucosamine sulfate also appears to positively interfere with the structural evolution of osteoarthritis by preventing joint space narrowing which characterizes the evolution of the disease. Encouraging results have also been obtained with chondroitin sulfate and diacerein. As for other molecules, new studies should be undertaken to confirm the results already obtained.

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