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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/92 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME16170388
PMID: | 16170388
LR: | 20061115
CED: | 20050919
DCO: | 20060612
Autoren: | Simánek V; Kren V; Ulrichová J; Gallo J
Titel: | The efficacy of glucosamine and chondroitin sulfate in the treatment of osteoarthritis: are these saccharides drugs or nutraceuticals?
Quelle: | Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia; VOL: 149 (1); p. 51-6 /200506/
PM: | Print
SU: | IM
Sprache: | English
CY: | Czech Republic
JID: | 101140142
ISSN: | 1213-8118
Institution: | Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Hnevotínská 3, Olomouc, 775 15, Czech Republic.
DT: | Journal Article; Research Support, Non-U.S. Gov't; Review
RN: | 40
Schlagwörter
CT: | CHONDROITIN SULFATES/chemistry; CHONDROITIN SULFATES/metabolism; CHONDROITIN SULFATES/*therapeutic use; DIETARY SUPPLEMENTS/*; GLUCOSAMINE/chemistry; GLUCOSAMINE/metabolism; GLUCOSAMINE/*therapeutic use; HUMANS; OSTEOARTHRITIS/*drug therapy; OSTEOARTHRITIS/metabolism; TREATMENT OUTCOME
CTG: | CHONDROITINSULFATE/Chemie; CHONDROITINSULFATE/Stoffwechsel; CHONDROITINSULFATE/*therapeutische Anwendung; NAHRUNGSERGÄNZUNGSMITTEL/*; GLUCOSAMIN/Chemie; GLUCOSAMIN/Stoffwechsel; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; OSTEOARTHROSE/*Arzneimitteltherapie; OSTEOARTHROSE/Stoffwechsel; BEHANDLUNGSERGEBNIS
TE: | Glucosamine/3416-24-8; Chondroitin Sulfates/9007-28-7
CR: | 3416-24-8; 9007-28-7
AB: | This review summarizes recent knowledge on the efficacy of glucosamine (GS) and/or chondroitin sulfate (CS) in the therapy of mild to moderate osteoarthritis (OA). OA, the most common joint disease is a significant source of disability, quality of life impairment and a considerable burden to any health care system. In the Czech Republic, glucosamine sulfate (GS) and chondroitin sulfate (CS) are available both as prescription drugs and as food supplements. Based on available data both are useful in the earlier stages of OA when combined with other modalities such as weight loss and exercises. They appear to relieve pain and improve range of the joint motion. In addition, they also display mild anti-inflammatory effects. However, controversy still exists over their ability to change significantly the natural history of the osteoarthritic joint. This effect is not easy to demonstrate for any other treatment modalities apart from joint replacement. Monitoring the cure efficacy by X-ray has been recently criticised and hence future techniques are anticipated for this reason. Further, long-term oral administration is required to obtain slightly increased levels of GS and/or CS in human blood. Both reviewed saccharides are well tolerated with negligible adverse reactions. In conclusion, the authors suggest that GS and CS should be classified as food supplements only.

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