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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME11090115
PMID: | 11090115
LR: | 20061115
CED: | 20001220
DCO: | 20010201
Autoren: | Blot L; Marcelis A; Devogelaer JP; Manicourt DH
Titel: | Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human cartilage.
Quelle: | British journal of pharmacology; VOL: 131 (7); p. 1413-21 /200012/
PM: | Print
SU: | IM
Sprache: | English
CY: | ENGLAND
JID: | 7502536
ISSN: | 0007-1188
CO: | BJPCBM
Institution: | ICP Christian de Duve Institute of Cellular Pathology, Saint-Luc University Hospital, Catholic University of Louvain in Brussels, Brussels, Belgium.
DT: | In Vitro; Journal Article; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/*pharmacology; CARTILAGE, ARTICULAR/*drug effects; CARTILAGE, ARTICULAR/metabolism; CULTURE TECHNIQUES; DICLOFENAC/analogs & derivatives; DICLOFENAC/pharmacology; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR MATRIX/drug effects; EXTRACELLULAR MATRIX/metabolism; HUMANS; HYALURONIC ACID/*metabolism; OSTEOARTHRITIS/*metabolism; PROTEOGLYCANS/*drug effects; PROTEOGLYCANS/metabolism; THIAZINES/pharmacology; THIAZOLES/pharmacology
CTG: | ANTIPHLOGISTIKA, NICHTSTEROIDALE/*Pharmakologie; KNORPEL, GELENK-/*Arzneimittelwirkungen; KNORPEL, GELENK-/Stoffwechsel; LABORKULTUREN, TECHNIKEN FÜR; DICLOFENAC/Analoge & Derivate; DICLOFENAC/Pharmakologie; DOSIS-WIRKUNGSBEZIEHUNG, ARZNEIMITTEL-; EXTRAZELLULÄRMATRIX/Arzneimittelwirkungen; EXTRAZELLULÄRMATRIX/Stoffwechsel; MENSCH; HYALURONSÄURE/*Stoffwechsel; OSTEOARTHROSE/*Stoffwechsel; PROTEOGLYCANE/*Arzneimittelwirkungen; PROTEOGLYCANE/Stoffwechsel; THIAZINE/Pharmakologie; THIAZOLE/Pharmakologie
TE: | Anti-Inflammatory Agents, Non-Steroidal; Proteoglycans; Thiazines; Thiazoles; Diclofenac/15307-86-5; meloxicam/71125-38-7; aceclofenac/89796-99-6; Hyaluronic Acid/9004-61-9
CR: | 15307-86-5; 71125-38-7; 89796-99-6; 9004-61-9
AB: | 1. Since nonsteroidal anti-inflammatory drugs (NSAIDs) may impair the ability of the chondrocyte to repair its damaged extracellular matrix, we explored the changes in the metabolism of newly synthesized proteoglycan and hyaluronan (HA) molecules produced by aceclofenac, diclofenac and meloxicam in human osteoarthritic (OA) cartilage. 2. Explants were sampled from the medial femoral condyle and were classified by use of the Mankin's histological-histochemical grading system. Cartilage specimens exhibited moderate (M) OA in 20 subjects and had severe (S) OA in 20. 3. Cartilage explants were pulsed with [-3H]-glucosamine and chased in the absence or in the presence of 0.3 - 3 microg ml(-1) of either aceclofenac, diclofenac or meloxicam. After papain digestion, the labelled chondroitin sulphate ([-3H]-proteoglycans) and [-3H]-HA molecules present in the tissue and media were purified by anion-exchange chromatography. 4. In cartilage with MOA and SOA, the metabolic balance of proteoglycan and HA was unaffected by diclofenac. In contrast, and in a dose-dependent manner, aceclofenac and meloxicam both increased the synthesis of proteoglycans and HA in explants with MOA and SOA; these two NSAIDs also reduced significantly the net loss of [-3H]-proteoglycans and [-3H]-HA molecules from cartilage explants. 5. The data obtained in short-term in vitro cultures indicate that, at the concentrations found in synovial fluid, aceclofenac and meloxicam may exert a favourable effect on the overall metabolism of proteoglycans and HA in cartilage with MOA and SOA.

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