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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME10990186
PMID: | 10990186
LR: | 20051117
CED: | 20001227
DCO: | 20010104
Autoren: | Creamer P
Titel: | Osteoarthritis pain and its treatment.
Quelle: | Current opinion in rheumatology; VOL: 12 (5); p. 450-5 /200009/
PM: | Print
SU: | IM
Sprache: | English
CY: | UNITED STATES
JID: | 9000851
ISSN: | 1040-8711
CO: | CORHES
Institution: | Southmead Hospital, Bristol, UK. pcreamer@btinternet.com
DT: | Journal Article; Review
RN: | 56
Schlagwörter
CT: | ACETAMINOPHEN/therapeutic use; ANALGESICS, NON-NARCOTIC/therapeutic use; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/therapeutic use; ARTHRALGIA/*etiology; ARTHRALGIA/physiopathology; ARTHRALGIA/*therapy; ARTHROPLASTY, REPLACEMENT; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS/therapeutic use; EXERCISE THERAPY; GLUCOSAMINE/therapeutic use; HUMANS; ISOENZYMES/metabolism; MEMBRANE PROTEINS; NITRIC OXIDE/metabolism; OSTEOARTHRITIS/*complications; OSTEOARTHRITIS/therapy; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES/metabolism; PROSTAGLANDINS/biosynthesis; SUBSTANCE P/metabolism
CTG: | ACETAMINOPHEN/therapeutische Anwendung; ANALGETIKA, NICHTNARKOTISCHE/therapeutische Anwendung; ANTIPHLOGISTIKA, NICHTSTEROIDALE/therapeutische Anwendung; ARTHRALGIE/*Ätiologie; ARTHRALGIE/Pathophysiologie; ARTHRALGIE/*Therapie; ARTHROPLASTIK, ERSATZ-; CYCLOOXYGENASE 2; CYCLOOXYGENASE-2-INHIBITOREN; CYCLOOXYGENASEINHIBITOREN/therapeutische Anwendung; BEWEGUNGSTHERAPIE; GLUCOSAMIN/therapeutische Anwendung; MENSCH; ISOENZYME/Stoffwechsel; MEMBRANPROTEINE; STICKSTOFFMONOXID/Stoffwechsel; OSTEOARTHROSE/*Komplikationen; OSTEOARTHROSE/Therapie; PROSTAGLANDIN-ENDOPEROXID-SYNTHASE/Stoffwechsel; PROSTAGLANDINE/Biosynthese; SUBSTANZ P/Stoffwechsel
TE: | Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Membrane Proteins; Prostaglandins; Nitric Oxide/10102-43-9; Acetaminophen/103-90-2; Substance P/33507-63-0; Glucosamine/3416-24-8; Cyclooxygenase 2/E.C. 1.14.99.1; PTGS2 protein, human/E.C. 1.14.99.1; Prostaglandin-Endoperoxide Synthases/E.C. 1.14.99.1
CR: | 10102-43-9; 103-90-2; 33507-63-0; 3416-24-8; E.C. 1.14.99.1; E.C. 1.14.99.1; E.C. 1.14.99.1
AB: | Pain is the most important symptom of osteoarthritis (OA) and the reason why individuals seek medical treatment. The anatomic cause is unclear and is likely to vary between individuals. Recent work confirms the heterogeneity of pain in OA with differences in severity, location, precipitating and relieving factors, and response to intra-articular anesthetic. Nonpharmacologic treatment of OA is important and evidence is now accumulating for interventions such as aerobic exercise, quadriceps exercises, footwear modification, education, and social support. Analgesia remains the first choice drug therapy: compounds more potent than acetaminophen are now available and effective. New cyclooxygenase-2 (COX-2) inhibitors may have a role in subjects for whom simple analgesia is inadequate. Glucosamine is a simple, safe product that appears to have a weak pain-relieving effect, and intra-articular hyaluronate injections may also have a limited role. Recent community studies confirm the benefit of joint replacement in OA, though a number of questions remain about the timing, indications, and alternatives to surgery.

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