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ND: | ME06583411
PMID: | 6583411
LR: | 20061115
CED: | 19840412
DCO: | 19840412
Autoren: | Adams ME
Titel: | Target tissue models: cartilage changes in experimental osteoarthritis in the dog.
Quelle: | The Journal of rheumatology. Supplement; VOL: 11; p. 111-3 /198312/
PM: | Print
SU: | IM
Sprache: | English
CY: | CANADA
JID: | 7806058
ISSN: | 0380-0903
CO: | JRSUDX
DT: | Journal Article; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ANIMALS; CARTILAGE, ARTICULAR/*metabolism; DISEASE MODELS, ANIMAL; DOGS; FEMALE; GLYCOSAMINOGLYCANS/metabolism; MENISCI, TIBIAL/metabolism; OSTEOARTHRITIS/*metabolism; PROTEOGLYCANS/metabolism
CTG: | TIER; KNORPEL, GELENK-/*Stoffwechsel; KRANKHEITSMODELLE, TIER; HUNDE; WEIBLICH; GLYCOSAMINO-GLYCANE/Stoffwechsel; MENISKEN, KNIEGELENK-/Stoffwechsel; OSTEOARTHROSE/*Stoffwechsel; PROTEOGLYCANE/Stoffwechsel
TE: | Glycosaminoglycans; Proteoglycans
AB: | Transection of the anterior cruciate ligament in the dog knee leads to a reproducible defined osteoarthritis (OA) with erosive cartilage loss, subchrondral sclerosis, and osteophyte formation, enabling studies of cartilage biochemistry before morphological changes are apparent. As early as 1 week after operation, menisci showed increased water content , 20% loss of galactosamine, and 40% loss of glucosamine. There was increased synthesis of larger proteoglycans (PG) at 3, 6, and 12 weeks, and the synthesis was greater in the menisci than the articular cartilage. there was no apparent impairment of the PG ability to aggregate with hyaluronate.

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