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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/389 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME07451514
PMID: | 7451514
LR: | 20061115
CED: | 19810324
DCO: | 19810324
Autoren: | Mankin HJ; Johnson ME; Lippiello L
Titel: | Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. III. Distribution and metabolism of amino sugar-containing macromolecules.
Quelle: | The Journal of bone and joint surgery. American volume; VOL: 63 (1); p. 131-9 /198101/
PM: | Print
SU: | AIM IM
Sprache: | English
CY: | UNITED STATES
JID: | 0014030
ISSN: | 0021-9355
CO: | JBJSA3
DT: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
NG: | AM 16265-07 AM NIADDK
Schlagwörter
CT: | AGED; AMINO SUGARS/*biosynthesis; CARTILAGE, ARTICULAR/*metabolism; GALACTOSAMINE/metabolism; GLUCOSAMINE/metabolism; HIP JOINT/*metabolism; HUMANS; MACROMOLECULAR SUBSTANCES; MIDDLE AGED; OSTEOARTHRITIS/*metabolism; SULFUR OXIDES/metabolism; SULFUR RADIOISOTOPES; TRITIUM
CTG: | ALTE MENSCHEN; AMINOZUCKER/*Biosynthese; KNORPEL, GELENK-/*Stoffwechsel; GALACTOSAMIN/Stoffwechsel; GLUCOSAMIN/Stoffwechsel; HÜFTGELENK/*Stoffwechsel; MENSCH; MAKROMOLEKULARE SUBSTANZEN; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE/*Stoffwechsel; SCHWEFELOXIDE/Stoffwechsel; SCHWEFELRADIOISOTOPE; TRITIUM
TE: | Amino Sugars; Macromolecular Substances; Sulfur Oxides; Sulfur Radioisotopes; Tritium/10028-17-8; Glucosamine/3416-24-8; Galactosamine/7535-00-4
CR: | 10028-17-8; 3416-24-8; 7535-00-4
AB: | Since 1960, numerous studies have supported the thesis that the synthetic activity of articular chondrocytes is increased in osteoarthritis, but several recent reports have challenged this concept. To clarify this problem fully and also to define further the products of this increased synthesis, three experiments were performed in which the distribution and rates of synthesis of amino sugar-containing macromolecules in normal and osteoarthritic cartilage from the human femoral head were assessed by biochemical analysis and studies of the incorporation of 3H-glucosamine and 35SO4. The biochemical data obtained clearly demonstrated the previously noted significant decrease in hexosamine content in osteoarthritic tissue. This decrease was principally due to a diminution in glucosamine concentration and correlated inversely with the severity of the disease process (as measured by a previously described histological-histochemical grading system). Metabolic studies showed a marked increment in the rates of incorporation of 3H-glucosamine into both the glucosamine and the galactosamine fractions of the cartilage. The increased synthesis correlated directly in a non-linear fashion with the severity of the disease. The ratio of the rate of incorporation of 3H-glucosamine into the glucosamine fraction to the rate of its incorporation into the galactosamine fraction was the same in normal and osteoarthritic samples, suggesting that the decline in glucosamine concentration was not related to a qualitative alteration of synthetic activity.

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