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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/394 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME07403255
PMID: | 7403255
LR: | 20031114
CED: | 19801021
DCO: | 19801021
Autoren: | Adam M; Musilova J; Krabcova M; Brettschneider I; Pesakova V; Deyl Z
Titel: | Effect of cartilage bone marrow extract on the metabolism of collagen in osteoarthrotic cartilage.
Quelle: | Pharmacology; VOL: 21 (1); p. 53-8 /1980/
PM: | Print
SU: | IM
Sprache: | English
CY: | SWITZERLAND
JID: | 0152016
ISSN: | 0031-7012
CO: | PHMGBN
DT: | Journal Article
Schlagwörter
CT: | ANIMALS; BONE MARROW/*physiology; CARTILAGE/*physiology; CARTILAGE, ARTICULAR/metabolism; CHICK EMBRYO; COLLAGEN/*metabolism; GLUCOSAMINE/metabolism; LEUCINE/metabolism; OSTEOARTHRITIS/*metabolism; PROLINE/metabolism; PROTEOGLYCANS/metabolism; TISSUE EXTRACTS/*pharmacology
CTG: | TIER; KNOCHENMARK/*Physiologie; KNORPEL/*Physiologie; KNORPEL, GELENK-/Stoffwechsel; HÜHNEREMBRYO; KOLLAGEN/*Stoffwechsel; GLUCOSAMIN/Stoffwechsel; LEUCIN/Stoffwechsel; OSTEOARTHROSE/*Stoffwechsel; PROLIN/Stoffwechsel; PROTEOGLYCANE/Stoffwechsel; GEWEBEEXTRAKTE/*Pharmakologie
TE: | Proteoglycans; Tissue Extracts; Proline/147-85-3; Glucosamine/3416-24-8; Leucine/61-90-5; Collagen/9007-34-5
CR: | 147-85-3; 3416-24-8; 61-90-5; 9007-34-5
AB: | The effect of cartilage bone marrow extract (CBME) on the metabolism of collagen and proteoglycan in crude embryo and human cartilage was investigated. While in chick embryos' articular cartilages the increased levels of radioactivity in collagen and proteoglycan were observed, in normal human cartilage only slight changes were detected. In osteoarthrotic cartilages, however, a marked increase in radioactivity was found in collagen and in the proteoglycan fraction containing the glycoprotein link. A blockade of collagenolysis by CBME treatment is suggested.

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