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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME10985908
PMID: | 10985908
LR: | 20051117
CED: | 20001108
DCO: | 20001108
Autoren: | Russell AL; McCarty MF
Titel: | Glucosamine for migraine prophylaxis?
Quelle: | Medical hypotheses; VOL: 55 (3); p. 195-8 /200009/
PM: | Print
SU: | IM
Sprache: | English
CY: | SCOTLAND
JID: | 7505668
ISSN: | 0306-9877
CO: | MEHYDY
Institution: | Brampton Pain Clinic, Bramalea, Ontario, Canada.
DT: | Journal Article
Schlagwörter
CT: | GLUCOSAMINE/pharmacology; GLUCOSAMINE/*therapeutic use; HEPARIN/administration & dosage; HUMANS; MAST CELLS/drug effects; MAST CELLS/physiology; MIGRAINE DISORDERS/*drug therapy
CTG: | GLUCOSAMIN/Pharmakologie; GLUCOSAMIN/*therapeutische Anwendung; HEPARIN/Verabreichung & Dosierung; MENSCH; MASTZELLEN/Arzneimittelwirkungen; MASTZELLEN/Physiologie; MIGRÄNE/*Arzneimitteltherapie
TE: | Glucosamine/3416-24-8; Heparin/9005-49-6
CR: | 3416-24-8; 9005-49-6
AB: | Following a fortuitous observation that migraine headaches ceased in a patient receiving glucosamine therapy for osteoarthritis, a further ten patients with migraine or migraine-like vascular headaches, refractory to established preventive or abortive therapies, have been treated with daily oral glucosamine. After a lag of 4-6 weeks, a substantial reduction in headache frequency and/or intensity has been noted; in some cases, the benefit appears to be dose-dependent. Since glucosamine can be a rate-limiting precursor for mucopolysaccharide synthesis, it is germane to note previous reports that heparin and pentosan polysulfate may have migraine-preventive activity. There is reason to suspect that mast cells are central mediators of the neurogenic inflammation associated with migraine and cluster headaches. The heparin produced by mast cells may function to provide feedback down-regulation of mast cell activation, and exerts a range of other anti-inflammatory effects. We postulate that supplemental glucosamine can boost mast cell heparin synthesis - perhaps correcting a functional heparin deficiency - thereby preventing or ameliorating the neurogenic inflammation that mediates pain in vascular headache. Whether or not this idea has validity, a controlled study of glucosamine for migraine prophylaxis appears to be warranted.

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