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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/348 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME09710325
PMID: | 9710325
LR: | 20051116
CED: | 19981022
DCO: | 19981022
Autoren: | McCarty MF
Titel: | Enhanced synovial production of hyaluronic acid may explain rapid clinical response to high-dose glucosamine in osteoarthritis.
Quelle: | Medical hypotheses; VOL: 50 (6); p. 507-10 /199806/
PM: | Print
SU: | IM
Sprache: | English
CY: | ENGLAND
JID: | 7505668
ISSN: | 0306-9877
CO: | MEHYDY
Institution: | Nutrition 21, San Diego, CA 92109, USA.
DT: | Journal Article; Review
RN: | 40
Schlagwörter
CT: | ANIMALS; GLUCOSAMINE/administration & dosage; GLUCOSAMINE/*therapeutic use; HUMANS; HYALURONIC ACID/*biosynthesis; OSTEOARTHRITIS/*drug therapy; SYNOVIAL MEMBRANE/drug effects; SYNOVIAL MEMBRANE/*metabolism
CTG: | TIER; GLUCOSAMIN/Verabreichung & Dosierung; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; HYALURONSÄURE/*Biosynthese; OSTEOARTHROSE/*Arzneimitteltherapie; SYNOVIALMEMBRAN/Arzneimittelwirkungen; SYNOVIALMEMBRAN/*Stoffwechsel
TE: | Glucosamine/3416-24-8; Hyaluronic Acid/9004-61-9
CR: | 3416-24-8; 9004-61-9
AB: | Anecdotal reports of rapid symptomatic response to high-dose glucosamine in osteoarthritis are not credibly explained by the traditional view that glucosamine promotes synthesis of cartilage proteoglycans. An alternative or additional possibility is that glucosamine stimulates synovial production of hyaluronic acid (HA), which is primarily responsible for the lubricating and shock-absorbing properties of synovial fluid. Many clinical and veterinary studies have shown that intra-articular injections of high-molecular-weight HA produce rapid pain relief and improved mobility in osteoarthritis. HA has anti-inflammatory and analgesic properties, and promotes anabolic behavior in chondrocytes. The concentration and molecular weight of synovial fluid HA are decreased in osteoarthritis; by reversing this abnormality, high-dose glucosamine may provide rapid symptomatic benefit, and in the longer term aid the repair of damaged cartilage.

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