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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME12610812
PMID: | 12610812
LR: | 20061115
CED: | 20030228
DCO: | 20030618
Autoren: | Cohen M; Wolfe R; Mai T; Lewis D
Titel: | A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee.
Quelle: | The Journal of rheumatology; VOL: 30 (3); p. 523-8 /200303/
PM: | Print
SU: | IM
Sprache: | English
CY: | Canada
JID: | 7501984
ISSN: | 0315-162X
CO: | JRHUA9
Institution: | Department of Complementary Medicine, Faculty of Life Sciences, RMIT University, Bundoora, Australia. marc.cohen@rmit.edu.au
DT: | Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Schlagwörter
CT: | ADMINISTRATION, TOPICAL; ADULT; ANTIPRURITICS/*administration & dosage; CAMPHOR/*administration & dosage; CHONDROITIN SULFATES/*administration & dosage; DOUBLE-BLIND METHOD; FEMALE; GLUCOSAMINE/*administration & dosage; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE/*drug therapy; PAIN/drug therapy; PARASYMPATHOLYTICS/administration & dosage; PATIENT SATISFACTION; PLACEBOS; PLANT OILS/administration & dosage
CTG: | APPLIKATION, LOKALE; ERWACHSENER; ANTIPRURIGINOSA/*Verabreichung & Dosierung; CAMPHER/*Verabreichung & Dosierung; CHONDROITINSULFATE/*Verabreichung & Dosierung; DOPPELBLINDMETHODE; WEIBLICH; GLUCOSAMIN/*Verabreichung & Dosierung; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; SCHMERZEN/Arzneimitteltherapie; PARASYMPATHOLYTIKA/Verabreichung & Dosierung; PATIENTENZUFRIEDENHEIT; PLAZEBOS; PFLANZENÖLE/Verabreichung & Dosierung
TE: | Antipruritics; Parasympatholytics; Placebos; Plant Oils; Glucosamine/3416-24-8; Camphor/76-22-2; peppermint oil/8006-90-4; Chondroitin Sulfates/9007-28-7
CR: | 3416-24-8; 76-22-2; 8006-90-4; 9007-28-7
NOTE: | Comment in: J Rheumatol. 2004 Apr;31(4):826; author reply 826-7; Ref.PMID: 15095741; Comment in: J Rheumatol. 2004 Apr;31(4):826; author reply 826-7; Ref.PMID: 15095742; Erratum in: J Rheumatol. 2003 Nov;30(11):2512
AB: | OBJECTIVE: To assess the ability of a topical preparation of glucosamine sulfate and chondroitin sulfate to reduce pain related to osteoarthritis (OA) of the knee. METHODS: Sixty-three patients were randomized to receive either a topical glucosamine and chondroitin preparation or placebo to be used as required over an 8 week period. Efficacy was assessed using a visual analog scale (VAS) for pain as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the SF-36 questionnaire. RESULTS: VAS scores indicated a greater mean reduction in pain for the glucosamine/chondroitin preparation group (mean change -3.4 cm, SD 2.6 cm) compared to the placebo group (mean change -1.6 cm, SD 2.7 cm) after 8 weeks. After 4 weeks the difference between active and placebo groups in their mean reduction from baseline was 1.2 (95% CI 0.1 to 2.4, p = 0.03) and after 8 weeks was 1.8 (95% CI for difference between groups, 0.6 to 2.9 cm; p = 0.002). CONCLUSION: Topical application of glucosamine and chondroitin sulfate is effective in relieving the pain from OA of the knee and improvement is evident within 4 weeks.

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