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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/133 von 416 DIMDI: MEDLINE (ME60) © NLM

ND: | ME15553585
PMID: | 15553585
LR: | 20051116
CED: | 20041119
DCO: | 20050324
Autoren: | Owens S; Wagner P; Vangsness CT Jr
Titel: | Recent advances in glucosamine and chondroitin supplementation.
Quelle: | The journal of knee surgery; VOL: 17 (4); p. 185-93 /200410/
PM: | Print
SU: | IM
Sprache: | English
CY: | United States
JID: | 101137599
ISSN: | 1538-8506
Institution: | Department of Orthopedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif, USA.
DT: | Journal Article; Review
RN: | 85
Schlagwörter
CT: | CARTILAGE, ARTICULAR/physiopathology; CHONDROITIN SULFATES/*pharmacology; CLINICAL TRIALS; DRUG THERAPY, COMBINATION; GLUCOSAMINE/*pharmacology; HUMANS; OSTEOARTHRITIS, KNEE/*drug therapy; OSTEOARTHRITIS, KNEE/physiopathology
CTG: | KNORPEL, GELENK-/Pathophysiologie; CHONDROITINSULFATE/*Pharmakologie; KLINISCHE STUDIEN; ARZNEIMITTEL-KOMBINATIONSTHERAPIE; GLUCOSAMIN/*Pharmakologie; MENSCH; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; OSTEOARTHROSE, KNIE/Pathophysiologie
TE: | Glucosamine/3416-24-8; Chondroitin Sulfates/9007-28-7
CR: | 3416-24-8; 9007-28-7
AB: | Glucosamine and chondroitin are alternative solutions to previous pharmaceutical options for the treatment of osteoarthritis. This article describes the mechanisms of action, pharmacokinetics, recent findings, and upcoming studies of these two natural remedies. The majority of studies on the mechanisms behind glucosamine and chondroitin have been performed in vitro or on animal models; however, the results have shown favorable effects on the balance between cartilage matrix synthesis and degradation. The pharmacokinetics of the three main forms of glucosamine were compared, and glucosamine hydrochloride displayed the greatest compound purity, despite the compounds having equal oral absorption rates of 90%. Chondroitin sulfate has been the principal clinical formulation with a slightly lower oral absorption of 70%. Clinical trials were evaluated based on two categories-radiographic changes and symptom improvement of pain and function. Although adverse effects of these two remedies were minor, the quality and labeled quantity of these relatively unregulated products must be considered. More randomized controlled studies on humans in vivo need to evaluate the efficacy, long-term effects, and quality of these compounds.

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