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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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ND: | ME15552752
PMID: | 15552752
LR: | 20061115
CED: | 20041119
DCO: | 20050127
Autoren: | Van Linthoudt D; Gerster JC
Titel: | Les médicaments anti-arthrosiques d'action lente. Développements récents. Slow-acting anti-rheumatic agents: recent developments
Quelle: | Revue médicale de la Suisse romande; VOL: 124 (9); p. 565-7 /200409/
PM: | Print
SU: | IM
Sprache: | French
CY: | Switzerland
JID: | 0421524
ISSN: | 0035-3655
CO: | RMSRA6
Institution: | Services de Rhumatologie, Médecine physique et Réhabilitation. Daniel.VanLinthoudt@ne.ch
DT: | English Abstract; Journal Article; Review
RN: | 43
Schlagwörter
CT: | ANTIRHEUMATIC AGENTS/pharmacology; ANTIRHEUMATIC AGENTS/*therapeutic use; DELAYED-ACTION PREPARATIONS; HUMANS; OSTEOARTHRITIS/*drug therapy
CTG: | ANTIRHEUMATIKA/Pharmakologie; ANTIRHEUMATIKA/*therapeutische Anwendung; DEPOTPRÄPARATE; MENSCH; OSTEOARTHROSE/*Arzneimitteltherapie
TE: | Antirheumatic Agents; Delayed-Action Preparations
AB: | Until recently, treatment of osteoarthritis targeted the pain and the disability of the involved joints. It consisted in a mix of analgesics, anti-inflammatory drugs, steroid infiltrations and physical therapies. Usefulness of slow but long acting substances is increasing not only by their action on the symptoms but also because they positively influence the evolution of the disease. Some of them seem to induce a structural effect on the cartilage confirmed by a slow down of the joint space narrowing on successive radiographs of the knees. Presently, only basic matricial precursors such as chondroitin sulfate, glucosamine sulfate and hyaluronic acid are available in the clinic. They act by reducing cartilage destruction and enhancing chondrocyte anabolism. These preliminary results should be confirmed by further studies based on magnetic resonance imaging and surrogate markers of the cartilage matrix. Recent developments in the understanding of the physiopathology of osteoarthritis, including the key role of some cytokines, should allow new therapic ways, individually or in combination.

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