ND: |
ME11795556 |
PMID: |
11795556 |
LR: |
20051117 |
CED: |
20020117 |
DCO: |
20020201 |
Autoren: |
McColl GJ |
Titel: |
Pharmacological therapies for the treatment of osteoarthritis. |
Quelle: |
The Medical journal of Australia; VOL: 175 Suppl; p. S108-11 /20011119/ |
PM: |
Print |
SU: |
IM |
Sprache: |
English |
CY: |
Australia |
JID: |
0400714 |
ISSN: |
0025-729X |
CO: |
MJAUAJ |
Institution: |
Centre for Rheumatic Diseases, Royal Melbourne Hospital, Parkville, VIC. g.mccoll@medicine.unimelb.edu.au |
DT: |
Journal Article; Review |
RN: |
30 |
Schlagwörter |
CT: |
ACETAMINOPHEN/therapeutic use; ANALGESICS, NON-NARCOTIC/therapeutic use; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/therapeutic use; ARTHRITIS/*drug therapy; CYCLOOXYGENASE INHIBITORS/therapeutic use; HUMANS; LACTONES/therapeutic use; PYRAZOLES; SULFONAMIDES/therapeutic use; SULFONES |
CTG: |
ACETAMINOPHEN/therapeutische Anwendung; ANALGETIKA, NICHTNARKOTISCHE/therapeutische Anwendung; ANTIPHLOGISTIKA, NICHTSTEROIDALE/therapeutische Anwendung; ARTHRITIS/*Arzneimitteltherapie; CYCLOOXYGENASEINHIBITOREN/therapeutische Anwendung; MENSCH; LACTONE/therapeutische Anwendung; PYRAZOLE; SULFONAMIDE/therapeutische Anwendung; SULFONE |
TE: |
Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Lactones; Pyrazoles; Sulfonamides; Sulfones; rofecoxib; Acetaminophen/103-90-2; celecoxib/169590-42-5 |
CR: |
103-90-2; 169590-42-5 |
AB: |
Non-pharmacological interventions are the first-line therapy for osteoarthritis. If non-pharmacological therapy fails, paracetamol (up to 4 g daily) should be added. If paracetamol fails, the patient's risk factors for gastrointestinal and renal disease should be assessed. In patients with gastrointestinal risk factors, a COX-2-specific inhibitor (CSI) would be used in preference to a conventional non-steroidal anti-inflammatory drug (NSAID). In patients with renal risk factors, NSAIDs and CSIs should be used with care. In patients who continue to have problems, other treatments should be considered; these might include intra-articular hyaluronan or depot corticosteroid, analgesia or glucosamine. |